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B7-H1在慢性乙型肝炎肝组织中的表达及临床意义 被引量：1

Expression and Clinical Significance of B7-H1 in Chronic Hepatitis B
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摘要 目的研究共刺激分子B7-H1在慢性乙型肝炎(chronic hepatitis B,CHB)肝组织中的表达及临床意义。方法采用免疫组织化学和半定量逆转录聚合酶链反应(RT-PCR)检测30例CHB肝组织中B7-H1蛋白和mRNA的表达。结果30例CHB肝组织中18例(60%)肝组织中B7-H1表达阳性,11例正常人肝组织无表达。B7-H1分子的表达与肝组织炎症活动程度及纤维化进程密切相关。RT-PCR结果与其一致。结论B7-H1在慢性乙型肝炎感染者中明显增高,并与肝组织炎症活动程度相关,提示B7-H1在慢性乙型肝炎中担负着重要的免疫调节作用,可成为判断乙肝活动强弱的一个指标。 Objective To study the expression of B7-H1 mRNA and B7-H1 protein in liver tissue of patients with chronic hepatitis B （CHB）, and investigate its relevance to the pathogenesis. Methods The B7-H1 mRNA and B7-H1 protein expression were determined in liver tissues from 30 CHB patients and 11 healthy controls using irnmunohistochemistry assay and real-time PCR （RT-PCR）. Results B7-H1 expression was found to be 60% （18/30） of liver specimens in CHB patients, but none in 11 normal controls （P 〈0.05）. B7-H1 expression was closely correlated with the histological activity grades and the progress of hepatic fibrosis. Conclusion B7-H1 is increased in CHB patients and closely associated with histological and inflammatory grades in liver, suggesting that B7-H1 may play an active role in hepatitis B virus infection.
作者 孙趁意 唐芙爱 刘占举
机构地区 郑州大学第二附属医院消化内科
出处 《河南科技大学学报（医学版）》 2008年第2期94-96,共3页 Journal of Henan University of Science & Technology:Medical Science
基金 河南省卫生厅科技攻关项目(2005045)
关键词 慢性乙型肝炎 B7-H1 炎症 纤维化 chronic hepatitis B B7-H1 inflammation fibrosis
分类号 R512.62 [医药卫生—内科学]
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参考文献6

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同被引文献14

  • 1朱德强,黄志勇.DNA损伤与肝癌发生[J].世界华人消化杂志,2007,15(16):1775-1780. 被引量：12
  • 2Greenwald RJ, Freeman GJ, Sharpe AH. The B7 family revisited. Annu Rev Immunol 2005; 23t 515-548 .
  • 3Keir ME, Butte MJ, Freeman GJ, Sharpe AH. PD-1 and its ligands in tolerance and immunity. Annu Rev Immunol 2008; 26:677-704.
  • 4Okazaki T, Honjo T. The PD-1-PD-L pathway in immunological tolerance. Trends Immunol 2006; 27: 195-201.
  • 5Liu Z, Jiu J, Liu S, Fa X, Li F, Du Y. Blockage of tumor necrosis factor prevents intestinal mucosal inflammation through down-regulation of interleukin-23 secretion. J Autoimmun 2007; 29: 187-194.
  • 6Curiel TJ, Wei S, Dong H, Alvarez X, Cheng P, Mottram P, Krzysiek R, Knutson KL, Daniel B, Zimrnermann MC, David O, gurow M, Gordon A, Dhurandhar N, Myers L, Berggren R, Hemminki A, Alvarez RD, Ernilie D, Curiel DT, Chen L, Zou W. Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity. Nat Med 2003; 9: 562-567.
  • 7Mazanet MM, Hughes CC. B7-H1 is expressed by human endothelial cells and suppresses T cell cytokine synthesis. J Immunol 2002; 169:3581-3588.
  • 8Dong H, Strome SE, Salomao DR, Tamura H, Hirano F, Flies DB, Roche PC, Lu J, Zhu G, Tamada K, Lennon VA, Celis E, Chen L. Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nat Med 2002; 8: 793-800.
  • 9Iwai Y, Ishida M, Tanaka Y, Okazaki T, Honjo T, Minato N. Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade. Proc Natl Acad Sci U S A 2002; 99:12293-12297.
  • 10Strome SE, Dong H, Tamura H, Voss SG, Flies DB, Tamada K, Salomao D, Cheville J, Hirano F, Lin W, Kasperbauer JL, Ballman KV, Chen L. B7-H1 blockade augments adoptive T-cell immunotherapy for squamous cell carcinoma. Cancer Res 2003; 63: 6501-6505.

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河南科技大学学报（医学版）
2008年 第2期

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