CA-153对恶性胸腔积液诊断价值的meta分析

Diagnostic value of carbohydrate antigen (CA) 153 for malignant pleural effusion: a meta-analysis

目的糖类抗原CA-153在鉴别良恶性胸腔积液方面的作用尚未明确,本研究旨在探讨CA-153对恶性胸腔积液(MPE)的诊断效能。方法我们搜索多个数据库,对其中的英文文献进行系统评价,用随机效应模型得到纳入研究的总灵敏度、特异度以及其它指标,绘制汇总受试者工作特征曲线以探讨此次试验的总体诊断特性。结果按照选择标准最终有11项独立研究纳入本次meta分析。CA-153浓度诊断恶性胸腔积液的总灵敏度与特异度分别为0.51和0.96。此次试验所得汇总受试者工作特征曲线显示胸水CA-153测定诊断MPE效能较低。结论用CA-153单独诊断MPE效能较低,应结合临床表现及其它常规检验结果进行综合分析。

Objective The roles of tumor markers in differentiating malignant pleural effusion （MPE） from benign effusions are not clear yet. The aim of the present study was to to establish the overall diagnostic accuracy of the measurements of carbohydrate antigen 153 （ CA-153 ） for MPE. Methods After a systematic review of English language studies, sensitivity, specificity, and other measures of value of pleural concentrations of CA-153 in the diagnosis of MPE were pooled by using random effects models. Summary receiver operating characteristic curves were used to summarize overall test performance, Results Eleven studies met our inclusion criteria for the analysis. The summary estimates of the sensitivity and specificity of CA-153 were 0.51 and 0.96,respectively, for diagnosing MPE. Conclusions The current evidences do not recommend using CA- 153 alone for the diagnosis of MPE. The results of tumor marker assays should be interpreted in parallel with clinical findings and the results of conventional tests.