摘要
目的讨血清KL-6(Krebs Von den Lungen-6)在放射性损伤监测中的临床意义。方法ELISA法监测了30名接受放疗的肺部原发和继发恶性肿瘤患者血清KL-6的动态改变。结果名发生放射性肺炎患者在出现临床症状前血清KL-6水平即显著升高,并呈现肺部病变范围越广泛严重者,血清KL-6水平越高的倾向。给予糖皮质激素治疗后,随着临床症状和肺部影像的改善,血清KL-6水平逐渐下降,少数患者血清KL-6持续较高水平,肺部影像学则表现为较广范围的肺间质纤维化。结论肺部恶性肿瘤接受放疗的患者,血清KL-6水平的动态监测有利于较早预知放射性肺炎的发生和评价治疗效果。
Objective To investigate the clinical significance of serum KL-6 in detection of radiation injury Methods 30 cases of lung idiopathic and secondary malignant tumor that received radiotherapy underwent dynamic detection of serum KL-6 by means of ELISA.Results Serous level of KL-6 increased significantly in 7 patients with radiation pneumonitis before clinical symptoms appeared, which was prone to be higher with the more comprehensive range of pulmonary pathological changes.After the administration of glucocorticosteroids, with the improvement of clinical manifestations and chest radiographs, serous level of KL-6 decreased gradually.Among a few patients with persistent high level of KL-6, chest radiographs showed comprehensive pulmonary interstitial fibrosis.Conclusions Dynamic detection of serous level of KL-6 is conducive to early prognosis of radiation pneumonitis and evaluation of therapeutic efficacy in lung cancer patients with radiotherapy.
