二甲双胍和拜糖平对2型糖尿病降糖作用的临床疗效观察

目的观察应用二甲双胍和拜糖平对2型糖尿病的临床疗效。方法2型糖尿病患者60例,随机分为二甲双胍组32例和拜糖平组28例,疗程为24周。结果二甲双胍和拜糖平降低FBG(空腹血糖)的有效率分别为96.9%、85.7%,;P<0.01,对PBG(餐后2h血糖)的有效率分别为97.6%、93.8%,P<0.01,两种药物不刺激胰岛素的分泌。结论二甲双胍降低空腹血糖优于拜糖平,拜糖平降低餐后血糖的疗效优于二甲双胍,二者对胰岛素的分泌基本无影响。

Objective To observe the clinical effect between the metformin and acarbose in the treatment of type 2 diabetes mellitus. Methods Sixty patients were randomized into two groups and treated for 24weeks with either metformin （n=32）or acarbose （n=28） separately. Results The efficacy rate of reduction of FBG level with metformin and acarbose waere respectively 96.9%and 85.7% （P〈0.01）., and the efficacy rate of reduction of the PBG were respectively 93.8%and 97.6%（P〈0.01）.Conclusion The two drugs had no insulinotropic effect . Metformin is higher than that of acarbose to reduce of the FBG and acarbose is higher than that of metformin to reduce of the PBGo