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小鼠分娩前后子宫IL-17A及24p3表达变化的研究 被引量：1

Study on the expression of IL-17A and 24p3 in mouse uterus around birth
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摘要 选择雌性BALB/c小鼠作为动物模型,分别在未孕期、怀孕中期、分娩当天、分娩后一天和分娩五天5个不同时期剖取子宫和肝脏.RT-PCR检测不同时期IL-17A及24p3 mRNA在小鼠子宫及肝脏内的表达,HE组织染色检查淋巴细胞浸润程度.结果发现小鼠分娩前后IL-17A和24p3 mRNA在子宫内的表达呈正相关,两者可能参与了分娩前后子宫局部免疫炎症反应的调节. BALB/c were chose mice as animal model. The mice at five different stages, the nonpregnacy, the mid pregnancy, postpartum day 0, postpartum day 1, postpartum day 5, were dissected to obtain uterus and liver. The expression of IL-17A and 24p3 mRNA in the two tissues of different stages were detected by RTPCR, and the infiltration of lymphocyte was measured by HE. It was found that IL-17A and 24p3mRNA were expressed in a positive correlation level in mouse uterus around birth, and both of them could involve in the regulation of uterus immune inflammatory process around labour.
作者 宋桂芹 何波 王琛琛 梁素华 刘康 刘全胜
机构地区 四川大学生命科学学院 川北医学院医学生物学教研室
出处 《四川大学学报（自然科学版）》 CAS CSCD 北大核心 2008年第3期681-686,共6页 Journal of Sichuan University(Natural Science Edition)
基金 国家自然科学基金(30371307)
关键词 IL-17A 24p3 子宫 IL-17A, 24p3, uterus
分类号 Q75 [生物学—分子生物学]
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参考文献24

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同被引文献10

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  • 3Mvoseley TA,Haudenschild DR,Rose L,et al.Interleukin-17 family and IL-17 receptors[J].Cytokine Growth Factor Rev,2003,14(2),155-174.
  • 4Chabaud M,Lubberts E,Joosten L,et al.IL-17 derived from juxta-articular bone and synovium contributes to joint degradation in rheumatoid arthritis[J].Arthritis Res,2001,3(3):168-177.
  • 5Shen F,Hu Z,Goswami J,et al.Identification of common transcriptional regulatory elements in interleukin-17 target genes[J].J Biol Chem,2006,281 (34),24138-24148.
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  • 10何波,高闻达,宋桂芹,王琛琛,杨明理,刘全胜.24p3及白细胞介素17A在自身免疫性肝炎中的表达[J].中华肝脏病杂志,2007,15(9):709-710. 被引量：4

引证文献1

四川大学学报（自然科学版）
2008年 第3期

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