摘要
目的观察西酞普兰治疗脑卒中后抑郁(PSD)患者的疗效和不良反应。方法随机将80例脑卒中后抑郁患者分为西酞普兰组40例和对照组40例,于治疗前及治疗后第4周末,对两组患者进行Hamilton抑郁量表(HAMD))评定。结果治疗后,西酞普兰组患者的HAMD评分较治疗前差异有统计学意义(P<0.01),西酞普兰组的不良反应少且轻与对照组相比差异无统计学意义。结论西酞普兰治疗脑卒中后抑郁安全、有效。
Objeetive To observe the therapeutic effect of citalopram on post-stroke depression （PSD） and its reverse effect. Methods 80 PSD patients were randomly divided into citalopram group （n= 40） and control group （n=40）. Before treatment and at the end of 4th week after treatment, all patients in two groups were assessed with Hamilton Rating Scale for Depression （HAMD）. Results After treatment, HAMD of patients of citalopram group was decreased significantly （P〈0.01）. The reverse effect was little and slight in citalopram group. There wasn＇t significant difference of reverse effect between citalopram group and control group. Conclusion Citalopram is an effective and safe therapeutic drug in the treatment of PSD.
关键词
西酞普兰
脑卒中后抑郁
治疗
citalopram
post-stroke depression
therapy
