妊娠相关蛋白A在急性冠脉综合征中的诊断价值

Diagnostic Value of Pregnancy-Associated Protein A in Acute Coronary Syndromes

目的探讨妊娠相关蛋白A(PAPP-A)在急性冠脉综合征(ACS)中的诊断价值。方法观察对象分为急性心梗(AMI)、不稳定心绞痛(UAP)及健康对照三组,采集静脉血标本,每份标本同时测定PAPP-A与心肌酶(CK-MB)。结果AMI与UAP组之间PAPP-A结果无统计学意义(P=0.966),但两组结果均高于健康对照组(P均为0.000)。PAPP-A与CK-MB的ROC曲线下面积分别为■PAPP-A=0.875,■CK-MB=0.743,两曲线下面积比较u=2.50,P<0.05。结论PAPP-A作为急性冠脉综合征的诊断指标优于CK-MB,具有较好的诊断价值。

Objective To discuss the diagnostic value of pregnancy-associated protein A （PAPP-A） in acute coronary syndromes （ACS）. Methods Objects of observation were divided into three groups： acute myocardial infarction （AMI）, unstable angina pectoris （UAP） and normal control. Every vein blood sample was detected by PAPP-A test and MB isoenzyme of creatine kinase （CK-MB） test simultaneously. Statistical analysis was performed by SPSS 12.0 software. The data were analyzed by analysis of variance （ANOVA） and receiver operating characteristic （ROC） curve. Results There was no statistically significant difference between groups AMI and UAP in PAPP-A detection （ P = 0. 966）, but both of them were higher than the normal control group （ P = 0.000）. In ROC curve analysis, the areas of PAPP-A and CK-MB were 0. 875, 0.743 respectively. There was statistically significant difference in the areas comparison, u = 2.50, P 〈 0.05. Condusion As an ACS index, PAPP-A was better than CK-MB, it has a good diagnostic value.