实验性大鼠急性心肌缺血血浆蛋白C和D-二聚体检测的研究

Study on Changes of Protein C and D-dimer in Plasma of Experimental Rats with Acute Myocardium Ischemia

目的探讨垂体后叶素致急性心肌缺血的实验性大鼠血浆蛋白C和D-二聚体水平的变化和意义。方法50只大鼠随机分成正常对照组和实验模型组,腹腔注射垂体后叶素建立急性心肌缺血模型,观察注射垂体后叶素后心电图ST段变化以及血浆蛋白C活性和D-二聚体浓度生化指标。结果实验组血浆D-二聚体水平明显高于正常对照组(P<0.01),而血浆蛋白C活性检测与正常对照组没有明显差别(P>0.05)。结论血浆蛋白C不是垂体后叶素致实验性大鼠急性心肌缺血的主要因素,而D-二聚体增高参与了垂体后叶素致大鼠急性心肌缺血的过程。

Objective To study the clinical significance of plasma levels of protein C and D-dimer in experimental rats with pituitrin induced acute myocardium ischemia. Methods 50 rats were randomized into two groups： normal group and model group. Pituitrin was intra-abdominally injected to erect model of acute myocardium ischemia . The changes of electrocardiogram （ ST segment） and plasma levels of protein C and D- dimer were observed after injecting pituitrin. Result Model of acute myocardium ischemia was erected by injecting pituitrin intra-abdominally and the changes of electrocardiogram was observed. The level of D-dimer in model group was higher evidently than that in normal group（P 〈 0.01）, but there was no significant difference about the level of protein C between two groups（P 〉 0.05）. Conclusion Protein C was not main risk factor for acute myocardium ischemia induced by pituitrin in experimental rats, increased level of D-dimer was significant for acute myocardium ischemia induced by pituitrin.