摘要
目的探讨评价变应原脱敏治疗(SIT)对过敏性哮喘的疗效。方法利用计算机查找及筛选出pubmed(1966-2007)、cochrane图书馆(Issue2,2007、8)、BMBASE(-2007)、VIP(1989-2007)、中国生物医学文献数据库(CBMDISC)(1978-2007)、中国学术期刊全文数据库(CJFD)(1979-2007)等数据库中所需的文献。并手工检索相关资料,检索本领域专家近年来使用脱敏疗法治疗哮喘病的研究成果。并对纳入的研究的方法学质量按Cochrane协作网推荐的方法进行了评价。结果共纳入10篇随机对照试验(298例患者),描述性分析表明:与安慰剂组比较,脱敏疗法显著改善了哮喘患者的临床症状和减少了对药物的需求量,在提高FEV1值方面效果显著。脱敏治疗对哮喘患者生活质量的提高,也有统计学意义。结论脱敏技术在哮喘研究中已趋于完善,脱敏治疗能够改善患者的临床症状和肺部功能,并且能减少对药物的需求量。同时脱敏治疗的不良反应(比如过敏反应)发生率低,推荐用于临床。
Objective To examine evidence on the clinical effectiveness of allergen specific immuno- therapy for asthma. Methods Searching：PubMed, Embase,Cochrane library Chinese Biomedicine database and China Journal Fulltext Database et al. We handsearched the related published and unpublished data and their references. All trials about specific immunotherapy for asthma were included. The included studies were evaluated by two researchers independently. Results Ten RCTs involving 298 patients were included. The results of descriptlve-analysis were listed as the following：There was a significant reduction in asthma symptoms and medication following immunotherapy. There was also consistent effect on quality of life. Conclusion The review of trial found that allergen specific immunotherapy can reduce asthma symptoms, the need for medications,improve the sensitivity of the lungs and reduce the rate of side-effects（ such as anaphylaxis）.
出处
《中国实用医药》
2008年第18期57-59,共3页
China Practical Medicine
