PVA颗粒与中药白芨栓塞犬肾动脉的对比研究

Comparative study of renal arterial embolization with PVA particals and Bletilla Striata of Chinese traditional medicine

目的研究中药白芨颗粒及PVA(polyvinyl alcohol)颗粒分别部分栓塞实验犬肾动脉后的造影表现及病理变化,观察两者之间对肾脏影响有无差别,探讨应用白芨颗粒替代PVA颗粒用作栓塞剂的可行性。方法采用Seldinger技术,对25只健康家犬进行超选择性肾动脉部分栓塞,左肾用白芨颗粒,右肾用PVA颗粒。2周后,再次行双肾动脉造影观察血管栓塞情况。术后取病理,对比观察肾脏组织病理变化,将病理结果予以定量,综合评价脏器损伤。结果双侧肾动脉部分栓塞后两种处理对于肾组织损伤无明显差别,采用配对t检验,P>0.05。结论选择上述两种栓塞剂,对肾组织损伤效果一致。中药白芨颗粒具有良好的血管栓塞作用,使用方便、安全,是一种较理想的末梢型血管栓塞剂。

Objective To study the angiographic images and pathological changes of renal arterial embolization with polyvinyl alcohol （PVA）particals and Bletilla Striata. To observe the influences of the drugs respectively to kidney, and discuss the possibility of displacing PVA particals with Bletilla Striata. Methods Adopting the Seldinger technique, the left renal arteries were embolized partially with Bletilla Striata, and the right renal arteries partially with PVA particals in 25 dogs. After two weeks, the bilateral renal arterial embolization were reconfirmed by angiography, and pathological changes of the kidney tissues were compared and quantitatively analyzed alone with integral weighted method, for the evaluation of damaged organs. Results The samples of bilateral partial renal arterial embolized tissues were compared with matched T-Test between Bletilla Striata group and PVA particals group, showing no difference of kidney tissue changes after two kinds of treatments （P 〉 0.05）. Conclusions Experimental comparative study suggested that Bletilla Striata and PVA particals were equivalent in damage effects. Bletilla Striata is safe, simple and effective as a potential and reasonable peripheral embolization agent.