贲门失弛缓症介入治疗进展

Progress in intervention procedure of Achalasia

贲门失弛缓症是一种原发性食管运动障碍疾病,由下食管括约肌(LES)张力增高及松弛不良造成,主要表现为吞咽障碍,其发病机制目前尚不明确。各种治疗方法的目的均为降低LES的紧张性和阻滞性以缓解症状。目前治疗贲门失弛缓症的方法有药物治疗、肉毒毒素治疗、外科肌松解术、球囊导管成形术和贲门支架成形术。暂时性贲门支架成形术,是近年来使用的新介入治疗法,具有较好的优势和疗效,将成为治疗贲门失弛缓症的首选微创疗法。

Achalasia is a primary esophageal motility disorder, with the main symptom of dysphagia; and caused by the tonus increase and abnormal relaxation of the lower esophageal sphincter（LES）. The etiology remains unclear, the objective of the current treatment approaches for achalasia containing the reduction of the LES tone and obstruction to relieve the patients＂ symptoms; including pharmacologic treatment, botulinum toxin treatment, surgical myotomy, pneumatic dilatation and cardia stent dilatation. The temporary cardia stent dilatation possesses some better advantages and effects; and ought to be the first choice of minimal invasive interventional management for achalasia.