胰腺癌综合治疗现状及其价值

The current status and evaluation of comprehensive therapy of pancreatic carcinoma

任何单一疗法治疗胰腺癌都难以获得理想的疗效。目前,可切除胰腺癌的治疗仍以根治性切除为主。放射治疗与手术联合应用,可提高手术切除率,减少肿瘤扩散;术中放疗可以缓解疼痛,提高生存率;对术后辅助放化疗的作用仍有争议。区域性化疗理论上有诸多优势,但仍需数据支持。物理治疗和生物治疗在胰腺癌的治疗中也已经得到广泛的重视。但只有建立以手术切除为主,联合放疗、化疗、物理及生物治疗的综合治疗体系,才有可能根本改变治疗现状,显著提高长期生存率,并改善生活质量。介入治疗作为重要的姑息治疗方法之一,近年来得到了长足的发展。

The incidence of pancreatic carcinoma is increasing obviously in recent years with a serious threat to the people＇s life, and yet there is not a single treatment for obtaining satisfactory prognosis. At present, the radical resection is the primary method for resectable pancreatic carcinoma, together with radiotherapy can improve the surgical resection rate and reduce the dissemination of tumors. Intraoperative radiotherapy can alleviate the pain and increase the survival rate, but the role of postoperative radiotherapy and chemotherapy is still in controversial. There is a lot of advantages for regional chemotherapy theoretically, but lack of evidence in practice. Physical therapy and biological therapy in the treatment of pancreatic carcinoma have been recognized extensively. It is possible to change fundamentally the current status of treatment and to improve the long-term survival rates with the quality of life until establishing a comprehensive treatment system mainly depended on surgical resection with combination of radiotherapy, chemotherapy, physical and biological treatment. The interventional therapy has been significantly developed as an important palliative treatment during recent years.