彩色多普勒超声检测氯氮平所致脂肪肝的临床研究

A study of color doppler flow imaging to detect fatty liver caused by clozapine

目的探讨彩色多普勒超声检测技术在检测氯氮平所致脂肪肝的应用价值。方法应用Esaote Technos DU8型彩超仪,对337例精神分裂症患者服用氯氮平时间长短与所致脂肪肝关系进行了观察。结果337例长期服用氯氮平患者中,用药6个月被检出脂肪肝23例,检出率6.8%,用药9个月被检出脂肪肝139例,检出率41.2%。用药18个月被检出脂肪肝222例,检出率65.8%,差异有统计学意义(P<0.01)。结论脂肪肝彩超图与氯氮平用药时间存在关系。彩超在检测氯氮平所致脂肪肝上有一定价值,为精神科临床治疗提供科学依据。

Objective： To probe the value of using Color Doppler Flow Imaging（CDFI） to detect fatty liver caused by clozapine. Methods： The Esaote Technos DU8 were used to detexct fatty liver in three hundred and thirty - seven long - term clozapine treated schizophrenia patients. Results：Twenty - three （6.8%） of six - month - treatment patients were found had fatty liver and 139 （41.2%） of nine - month - treatment and 222 patients （ 65.8% ） of eighteen - month - treatment, and there was significant difference between then （ P 〈 0. 01 ）. Conclusion ： There was a relation between CDFI - found - fatty liver and the length of time of taking clozapine. CDFI has certain value in detecting clozapine caused fatty liver, and can provide some useful information for clinical psychiatric treatment.