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单剂量Nevirapine母婴阻断与HIV耐药

Prevention of mother-to-child transmission with single dose Nevirapine and human immunodeficiency virus drug resistance
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摘要 全球艾滋病的流行形势日趋严重,2007年15岁以下儿童感染者为250万,其中大部分是母婴传播,新感染人数为42万,死亡人数为33万,妇女艾滋病感染者为1540万。如果不接受抗病毒治疗,HIV感染儿童的预后很不乐观,大约有50%儿童在2周岁之前死亡。因此对HIV阳性孕妇及其婴儿实行母婴预防阻断措施,控制和降低儿童感染率,有着非常重要的现实意义。
作者 韩剑锋 蒋岩
出处 《中华流行病学杂志》 CAS CSCD 北大核心 2008年第7期730-733,共4页 Chinese Journal of Epidemiology
关键词 单剂量Nevirapine 母婴传播 艾滋病病毒 Single dose Nevirapine Mother-to-child transmission Human immunodeficiency virus
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  • 12007 AIDS epidemic update[OL].http://data. unaids. org/pub/ EPISlides/2007/2007 _ eplupdate _ en. pdf.
  • 2Ciuta ST, Boros S, Napoli PA, et al. Predictors of survival in children with acquired immuno-deficiency syndrome in Italy, 1983 to 1995. AIDS Patient Care STDS, 1998,12:629-637.
  • 3Newell ML, Coovadla H, Cortina-Borja M, et al. Mortality of infected and uninfected infants born to HIV-infected mothers in Africa: a pooled analysis. Lancet, 2004,364 : 1236-1243.
  • 4Connor EM,Sperling RS, Gelber R, et al. Reduction of maternalinfant transmission of human immunodeficiency virus type 1 with zidovudine treatment, Pediatric AIDS Clinical Trials Group Protocol 076 Study Group. N Engl J Med, 1994,331:1173-1180.
  • 5Guay LA,Musoke P, Fleming T, et al. Intrapartum and neonatal slngle-dose nevirapine compared with zidovudlne for prevention of mother-to-child transmission of HIV-1 in Kampala, Uganda: HIVNET 012 randomised trial. Lancet, 1999,354:795-802.
  • 6Jackson JB, Musoke P, Fleming T, et al. Intrapartum and neonatal single-dose nevirapine compared with zidovudine for prevention of mother-to child transmission of HIV-1 in Kampala, Uganda: 18-month follow-up of the HIVNET 012 randomised trial. Lancet, 2003,362:859 -868.
  • 7Taha TE,Kumwenda NI, Hoover DR, et al. Nevirapine and Zidovudine at birth to reduce perinatal transmission of HIV in an African setting. J Am Med Assoc, 2004,292 : 202-209.
  • 8WHO reconfirms its support for the use of nevirapine to prevent mother-to-child transmission of HIV (July 2003 )[OL]. http:// www. who. int/hiv/pub/mtct/en/NevirapineStatement072003.pdf.
  • 9Richman DD, Havlir D, Corbeil J, et al. Nevirapine resistance mutations of human immunodeficiency virus type 1 selected during therapy. J Virol, 1994,68 : 1660-1666.
  • 10Eshleman SH,Mracna M, Guay LA, et al. Selection and fading of resistance mutations in women and infants receiving nevirapine to prevent HIV 1 vertical transmission( HIVNET 012). AIDS, 2001, 15:1951-1957.

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