蔗糖诱发Sprague-Dawley雄性大鼠肥胖病高脂血症

The Obesity and Hyperlipemia Induced by Sucrose in Sprague-Davley Male Rats.

用蔗糖作辅助铁水，饲养刚离乳的Sprague－Dawley雄性大鼠，180天后，53％大鼠肥胖成为饮食诱发肥胖型大鼠（DIO大鼠），47％大鼠不肥胖成为饮食诱发肥胖抵抗型大鼠（DIO－R大鼠）且DIO和DIO－R大鼠均具高脂血症。说明25％蔗糖可诱发Sprague-Dawley雄性大鼠肥胖病高脂血症，但同样条件下为什么部分大鼠不肥胖还有待于进一步研究。另外，对DIO大鼠的肥胖机制作了初步探讨。

Timed wealing Sprague-Lhaler male rats had been drinking sucrose solution adlibitum be-sides water and food an libitum for 180 days. 53 Percent rats became dietary induced obesity(DIO) and 47 Percent rats became dietary induced obesity resistance (DIO-R). There were hy-perlipemia in dietary induced obesity and dietary induced obesity resistance rats. Suggesting thatdietary induced obesity rats with hyperlipemia were successfully made by using 25 percent sucrosesolution as auxiliary drinking-water. Moremover, The mechanism of dietary induced obesity inrats were investigated.