A new way to produce descending thoracic aorta dissection in the dogs

To construct a canine thoracic aortic dissection (TAD) model for later studying.Methods:we opened the thorax of the dog and exposed the aorta.The descending aorta right below the left innominated artery was clamped. The median was cut 1/3 in depth and 1/3 in circumference.Then the head of the balloon was put into the interspace of the median,the balloon was dilated after putting forward the tube,the normal saline was instilled into the interspace and a suit pressure was kept.The balloon proceeded alongside the separation of the median.After that the dasticity Protease was instilled into the separation maintained for 2 hours.The balloon was put out,the other 2/3 of the median in depth and the intima were cut.The external 1/3 part of the median and the adventitia were sutured.At last the chest wall was closed.Results:TAD model was established instantly,proved by angiography,MRI and autopsy.Conclusion:it is applica- ble to construction of a canine TAD model by this procedure.

To oonstruct a canine thoracic aortic dissection （TAD） model for later studying. Methods： we opened the thorax of the dog and exposed the aorta. The descending aorta right below the left innominated artery was damped. The median was cut 1/3 in depth and 1/3 in circumference. Then the head of the ballcon was put into the interspace of the median, the balloon was dilated after putting forward the tube, the normal saline was instilled into the interspace and a suit pressure was kept. The balloon proceeded alongside the separation of the median. After that the elasticity Protease was instilled into the separation maintained for 2 hours. The balloon was put out, the other 2/3 of the median in depth and the intima were cut. The external 1/3 part of the median and the adventitia were sutured. At last the chest wall was dosed. Results： TAD model was established instantly, proved by angiography, MRI and autopsy. Conclusion： it is applicable to construction of a canine TAD model by this procedure.