生长抑素通过中缝大核发挥镇痛和增强电针镇痛的作用

SOMATOSTATIN IN NRM PLAYS ROLES IN INDUCING ANALGESIA AND ENHANCING ELECTROACUPUNCTURE ANALGESIA

本工作以钾离子透入引起大鼠甩尾为痛指标，观察了中缝大核微量注射生长抑素、生长抑素的耗竭剂半胱胺和抗生长抑素血清对大鼠痛阈和电针镇痛效应的影响。中缝大核微量注射生长抑素可提高大鼠的痛阈，并使电针镇痛的效应加强。用半胱胺耗竭或用抗生长抑素血清中和中缝大核中的生长抑素，均可使大鼠的痛阈降低，并减弱电针镇痛的效应。这表明生长抑素可能通过中缝大核发挥镇痛和增强电针镇痛的作用。

The effects of microinjection of somatostatin(SS),somatostatin depletor cysteamine(CS) and anti somatostatin serum(ASSS) on the pain threshold (PT) and electroacupuncture(EA) analgesia were investigated in the rat The potassium iontophoresis induced tail flick was used to measure the pain threshold The “Zusanli” were stimulated with EA The results indicated that microinjection of SS into necleus raphe magnus (NRM),could elevate PT and enhance EA analgesia PT and EA analgesia were decreased when SS in NRM was depleted by CS or neutralized by ASSS These data revealed that SS in NRM plays important roles in inducing analgesia and enhancing electroacupuncture analgesia