白藜芦醇抑制人卵巢癌细胞株A2780细胞增殖及凋亡诱导作用

Proliferation inhibition and apoptosis inducement of resveratrol on Human Ovary Cancer A2780 cell lines

目的探讨白藜芦醇对卵巢癌细胞株A2780的生长抑制及凋亡诱导作用。方法50、100及200μmol／LRES分别作用12～72h后，MTT比色法检测细胞生长活性，末端TdT酶标记技术检测细胞凋亡。结果RES能显著抑制卵巢癌细胞株A2780的体外生长，呈时间与剂量依赖性；部分细胞出现凋亡形态学改变，RES能明显诱导卵巢癌细胞A2780凋亡，且呈时间与剂量依赖性。结论RES通过抑制细胞增殖、诱导细胞凋亡等机制，能显著地抑制卵巢癌细胞的体外生长。

Objective To investigate the effects of resveratrol on inhibiting proliferation and inducing apoptosis of Human Ovary Cancer A2780 cell lines. Methods The proliferation activity was detected by MTT assay, and apoptosis of by method of TUNEL apoptosis assay. Results Resveratrol could significantly inhibite the proliferat ion and induce the apoptosis of of A2780 cell in a time and does dependent manner. Conclusion Resveratrol can significantly inhibite the proliferation and induce the apoptosis of A2780 cell.