血脂异常对男性勃起功能影响的流行病学研究

A study on the epidemiology of the influence of abnormal serum lipid on male erectile function

目的探讨血脂异常对男性勃起功能的影响。方法于清晨空腹采集外周血标本,测定血清总胆固醇（TC）、总甘油三酯（TG）、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）的浓度。从上述4项结果中至少1项有异常的我院患者中随机选取200例男性患者,4项结果均正常的患者中随机选取200例男性患者,用勃起功能障碍国际指数问卷表（IIEF-5）评估这些患者的勃起功能,分析血脂异常对男性勃起功能的影响。结果血脂异常者勃起功能障碍（ED）的发病率为47%,血脂正常者ED的发病率为30%,两者的发病率差异有统计学意义（P=0.005）。其中,40-59岁人群ED的发病率在两组间有统计学差异。Logistic回归分析发现年龄、HDL、TC/HDL、冠心病、焦虑或抑郁、良性前列腺增生和长期服用影响勃起的药物史与ED的发病有关,除HDL为保护因素,其余均为危险因素。结论高血脂是影响男性勃起功能的一个重要因素,尤其对40-59岁的中年男性的勃起功能影响最明显。HDL水平的下降和TC/HDL比值的上升是ED的重要的危险因素。

Objective To investigate the influence of the abnormal serum lipid on male erectile function. Methods 200 male patients who had at least one item abnormal in total cholesterol（TC）, triglycerides（TG）, HDL and LDL were selected randomly, and other 200 male patients who had normal level of serum lipid in the four items were selected randomly. These 400 patients＇ erectile function were evaluated by the IIEF-5. Results The incidence of ED was 47% in abnormal serum lipid men.The incident of ED was 30% in normal serum lipid men. There were significant differences in the incidence of ED （P=0.005）. The incidence of ED among men aged 40-59 was significant differenct between abnormal serum lipid men and normal group. Logistic regression analysis indicated age, HDL, TC/HDL, coronary heart disease, depression or anxiety, BPH, long-term Prescription History were associated with erectile function. HDL was protective factor of erectile function, the others were risk factors of erectile function. Conclusion Hyperlipidemia is an important factor of male erectile function, especially among men aged 40-59. The reduction of HDL and the rise of TC/HDL ratio are important risk factors of ED.