绝经前子宫切除与自然绝经妇女骨代谢生化指标的临床观察

Study on the Bone Metabolism of Pre-menopausal Women with Hysterectomy and Postmenopausal Women

目的:观察绝经前子宫切除和自然绝经妇女骨代谢生化指标的变化。方法:对比观察绝经前行子宫切除妇女38例、自然绝经后妇女40例及生育期健康妇女40例的骨代谢血尿生化指标的变化。结果:绝经前子宫切除组和自然绝经组的尿钙、尿脱氧吡啶、血硷性磷酸酶、骨钙素明显高于生育期健康组(P<0.05);自然绝经组的尿钙、尿脱氧吡啶、血骨钙素高于绝经前子宫切除组(P<0.05),血硷性磷酸酶在两组差异无统计学意义(P>0.05)。结论:绝经前子宫切除和自然绝经后妇女骨生成和骨吸收均增加,自然绝经妇女骨转换率进一步升高。

Objective ： To observe the variation of bone metabolism in pre - menopausal women with hysterectomy and postmenopausal women. Methods： 38 pre-menopausal women with hysterectomy, 40 postmenopausal women and 40 fertile women were enrolled in this study. Urine Calcium（ Ca）, Deoxypyridinoline （ DPD）, serum alkaline pbosphatase （ALP） and Bone Gla Protein （BGP） were determined. Results ： The level of urine Ca, DPD, serum ALP and BGP in pre - menopausal women with hysterectomy and postmenopausal women were higher than those in fertile women（ P 〈 0. 05 ）. The level of urine Ca, DPD and serum BGP in postmenopausal women were higher than those in pre - menopausal women with hysterectomy（ P 〈 0. 05 ）. But there was no significantly difference in the level of serum ALP between the two groups（P〉0. 05）. Conclusion： Bone formation and bone absorption are all increased in pre - menopausal women with hysterectomy and postmenopausal women. Bone transformation rate is higher in postmenopausal women than that in others.