摘要
目的:研究PTEN基因(phosphatase and tensinhomolog deleted on chromosome ten)、血管内皮生长因子-C(vascular endotnelial growth factor C,VEGF-C)和血管内皮生长因子受体-3(vascularendotnelial growth factor receptor3,VEGFR-3)在胃癌及正常胃组织中的表达,探讨其在胃癌的发生、发展、浸润和转移中的作用。方法:选择临床病理资料齐全的胃癌蜡块标本54例,采用免疫组织化学SP法检测PTEN、VEGF-C和VEGFR-3在其中的表达。另取正常胃黏膜标本15例为对照组。采用χ2检验和相关分析。结果:胃癌组织中PTEN低表达,且在肿瘤浸润深、有淋巴转移、临床分期高、病理分化低时降低;VEGF-C高表达,且在肿瘤直径大、肿瘤浸润深、有淋巴转移、临床分期高、病理分化低时增高;VEGFR-3高表达,且肿瘤直径大、肿瘤浸润深、有淋巴转移、临床分期高时升高。胃癌组织中VEGF-C与VEGFR-3的表达呈正相关,PTEN与VEGF-C、VEGFR-3的表达均呈负相关(P<0.05)。结论:检测PTEN、VEGF-C和VEGFR-3在胃癌组织中的表达情况对胃癌的诊断、预防和预后判断有指导意义。
Objeetive： To Study the expression of PTEN, VEGF-C and VEGFR-3 in gastric cancer and normal gastric tissues. Methods： Fifty-four cases of gastric carcinoma specimens were selected with full ciinicopathological data, and another 15 cases of normal gastric mucosa specimens were selected as the control. S-P immunohistochemistry was used to measure the ex pression of PTEN, VEGF-C and VEGFR-3. The data were statistically analyzed by X^2 test and rela-tive analysis. Results： The expression of PTEN in gastric cancers was low and reduced with increased invasive depth clinical stages, histological differentiation and occurring of lymphatic metastasis. The expression of VEGF-C in gastric cancers was high and increased with increased diameter of tumor, invasive depth, clinical stages histological differentiation, and occumng of lymphatic metastasis. The expression of VEGFR-3 in gastric cancers was high, and increased with increased diameter of tumor, invasive depth and clinical stages, and occurring of lymphatic metastasis. The expression of VEGF-C and VEGFR-3 were of positive correlation, and PTEN and VEGF-C, PTEN and VEGFR-3 were of inversely correlation in gastric cancers. Conclusion： The expression of PTEN, VEGF-C and VEGFR-3 in gastric caners might be useful to estimate the prevention, diagnoses, therapy and prognosis of gastric cancer.
出处
《中国现代普通外科进展》
CAS
2008年第3期220-223,共4页
Chinese Journal of Current Advances in General Surgery
