摘要
目的:研究番石榴叶水煎剂对2型糖尿病大鼠胰岛素降解酶基因mRNA表达的影响。方法:随机选取以不同剂量的番石榴叶水煎剂灌胃的2型糖尿病大鼠、以安慰剂灌胃的2型糖尿病大鼠、以及正常对照各10只,用RT-PCR法测定肝细胞胰岛素降解酶基因mRNA的表达。结果:服用番石榴叶后,2型糖尿病大鼠的胰岛素降解酶基因mRNA的表达下降,而服用安慰剂的糖尿病大鼠上述指标无显著变化。结论:番石榴叶能降低2型糖尿病大鼠胰岛素降解酶基因的表达。
Objective：To study the effects of Guajava leaf decoction on mRNA expression insulin -degrading enzyme （IDE） of experimental rat model of type 2 diabetes mellitus. Methods： mRNA Expression of IDE was deter-mined by RT-PCR in 10 rats model of type 2 diabetes mellitus being treated with Guajava leaf decoction, 10 diabetic rats laking placebo and 10 normal subjects. Results ：Guajava leaf decoction caused a decrease in mRNA expression of IDE. No change of the index was observed in diabetic rats with placebo. Conclusion Guajava leaf decoction can re- duced the mRNA expression of IDE of rat model of type 2 diabetes mellitus.
出处
《牡丹江医学院学报》
2008年第3期10-12,共3页
Journal of Mudanjiang Medical University
基金
黑龙江省教育厅科研项目(11511427)
牡丹江医学院科研项目
关键词
番石榴叶
2型糖尿病
胰岛素降解酶
基因表达
Guajava leaf
Type 2 diabetes mellitus
IDE （ nsulin - degrading enzyme）
Gene expression
