柳珊瑚酸对小肠兴奋作用的动物实验

EXCITANT EFFECTS OF SUBEROGORGIN ON SMALL INTESTINE OF ANIMAL

柳珊瑚酸（suberogorgin，Sub）是从南海柳珊瑚Suberogoryiasp．中分离的一种新结构化合物。依剂量地提高小鼠小肠炭末推进速度，并兴奋离体兔十二指肠，其ED50＝7．1μmol·L－1。此作用可被阿托品（1μmol·L－1）完全拮抗，被吲哚美辛（170和350μmol·L－1）部分拮抗，但不被苯海拉明阻断，表明Sub的作用主要与M受体有关。

Suberogorgin(Sub) was isolated from deberogorgltr sp. of the South ChinaSeaThe prornoting-Velocity of chareoal powder in srnall inteshne of ndce was increasedin a doshependent mannr by Sub 0.5-2.0mg. kg-1 iv. Sub excited the isolatedrabbt duodnum with ED50=7.1μmol. L-1. Ths excitant achon of Sub wasantaonized by atropne of 1μmol. L-1, and partly blocked by indOInthacine of 170and 350μmo. L-1, but not affected by diphenhybone of 10μmol. L-1 The resultsindicated tha the excitant achon of Sub on duodnum was chiefly related to M-receptor