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环氧化酶-2在皮肤肿瘤中的表达及其临床意义

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摘要 研究发现,在长期使用非甾体抗炎药(NSAIDs)治疗的类风湿性关节炎患者中结肠癌的发病率下降40%-60%。体内外及动物模型等研究表明,NSAIDs的作用靶点是环氧化酶(cyclooxygenase,COX)。COX有两种异构体:COX-1和COX-2,已证明COX-2在多种内脏肿瘤中存在过表达,因此,COX-2与肿瘤的关系得到了普遍关注。我们应用免疫组化方法检测了COX-2在几种常见皮肤肿瘤组织中的表达,并探讨其临床意义。
出处 《中华皮肤科杂志》 CAS CSCD 北大核心 2008年第7期476-477,共2页 Chinese Journal of Dermatology
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参考文献8

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