幼年大鼠热卡限制对成年后胰岛β细胞功能的影响

Effect of caloric restriction at early age of rats on their islet β cell function in adulthood

将11周龄的SD大鼠随机分为对照组和热卡限制组，干预24周后比较两组大鼠的胰岛β细胞功能及氧化应激指标。结果显示，从幼年期开始的热卡限制能改善成年大鼠糖负荷后的早期胰岛素分泌相，并减缓氧化应激，这些现象与其体重下降有关。

Eleven-week-old SD rats were randomized into control and calorie restriction group. The pancreatic 13 cell function and oxidative stress indexes in the two groups were compared after 24-week intervention. The results showed that calorie restriction, which started from young age, improved the early insulin secretion after glucose loading and alleviated the oxidative stress in adult rats, which was related to the reduction of body weight.