摘要
研究补体因子H和肾上腺髓质素对高糖培养的HBZY-1大鼠系膜细胞转化生长因子β1（TGF-β1）及细胞外基质（ECM）分泌的影响。结果提示联合应用肾上腺髓质素和补体因子H可显著抑制HBZY-1细胞TGF-β1及ECM的过度分泌而表现出一定的肾脏保护作用。
The renal protective effect of complement factor H （CFH） and adrenomedullin （AM） on rat mesengial cells （ HBZY-1 ） cultured under high glucose levels was investigated. Resuhs indicated that AM and CFH inhibited the expressions of transforming growth factor-β1 and extracellular matrix in HBZY-1 cells, suggesting that CFH and AM in combination seem to show some renal protective effects on diabetic nephropathy.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2008年第3期319-321,共3页
Chinese Journal of Endocrinology and Metabolism
关键词
补体因子H
肾上腺髓质素
糖尿病
Complement factor H
Adrenomedullin
Diabetes mellitus
