期刊文献+

新抗癌药物诱导人类肿瘤细胞凋亡 被引量:1

Novel Anticancer Compounds Induce Apoptosis in Human Tumor Cells
下载PDF
导出
摘要 采用常规化疗药物治疗人类恶性肿瘤通常因为严重的副作用限制了其疗效的发挥.从而使得患者常常不能长期生存。因此,发现新的抗癌治疗策略具有非常重要的意义。在这篇文章中将描述最近在实验室通过筛选美国国立癌症研究所小分子化合物资料库而发现的新的抗癌药物,阐述其诱导人类肿瘤细胞凋亡的新动态。
机构地区 Department of Medicine
出处 《癌症》 SCIE CAS CSCD 北大核心 2008年第7期675-676,共2页 Chinese Journal of Cancer
  • 相关文献

参考文献24

  • 1Gartel A L, Tyner A L. The role of the cyclin-dependent kinase inhibitor p21 in apoptosis [J]. Mol Cancer Ther,2002,1 (8) :639-649.
  • 2Blagosklonny M V. Are p27 and p21 cytoplasmic oncoproteins? [J]. Cell Cycle, 2002,1 (6) :391-393.
  • 3Gartel A L, Radhakrishnan S K. Lost in transcription: p21 repression, mechanisms, and consequences [J].Cancer Res, 2005,65(10):3980- 3985.
  • 4Gartel A L. The conflicting roles of the cdk inhibitor p21 (C1P1/WAF1) in apoptosis [J]. Leuk Res, 2005,29 (11):1237-1238.
  • 5Radhakrishnan S K, Gartel A L. A novel transcriptional inhibitor induces apoptosis in tumor cells and exhibits antiangiogenic activity [J]. Cancer Res, 2006,66(6) :3264-3270.
  • 6Radhakrishnan S K, Halasi M, Bhat U G, et al, Proapoptotic compound ARC targets Akt and N-myc in neuroblastoma cells [J]. Oncogene, 2008,27 (5): 694-699.
  • 7Bhat U G, Gartel A L. Differential sensitivity of human colon cancer cell lines to the nucleoside analogs ARC and DRB [J]. Int J Cancer, 2008, 122 (6) : 1426-1429.
  • 8Bhat U G, Zipfel P A, Tyler D S, et al. Novel anticancer compounds induce apoptosis in melanoma cells [J]. Cell Cycle, 2008, In press.
  • 9Ahieri D C. Survivin, cancer networks and pathway-directed drug discovery [J]. Nat Rev Cancer, 2008,8(1):61- 70.
  • 10Mandelin A M 2nd, Pope R M. Myeloid cell leukemia-1 as a therapeutic target [J]. Expert Opin Ther Targets, 2007,11 (3) : 363-373.

同被引文献9

引证文献1

二级引证文献2

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部