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REN基因变异与降压药物作用下血压及相关临床表型变化的关系 被引量:1

Association of REN Variation and Response of Blood Pressure and Related Clinical Phenotypes under Antihypertensive Drugs
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摘要 目的探讨新疆哈萨克族原发性高血压患者肾素基因rs1464816基因型与研究对象服用降压药物前后血压及相关临床表型水平变化的关系。方法随机选择新疆18—69岁1218名哈萨克族农牧民进行高血压相关危险因素横断面调查,筛选出首次诊断为高血压并未接受过降压治疗和无其他并发症共计400人作为研究对象。研究对象随机分为两组,分别服用血管紧张素转换酶抑制剂卡托普利和B受体阻滞剂阿替洛尔。两组均服药3周,应用聚合酶链式反应一连接酶检测反应(PCR-LDR)检测研究对象肾素基因rs1464816基因型,分析其与服用降压药物前后研究对象血压及相关临床表型(包括血浆肾素、血管紧张素Ⅱ及醛固酮)水平变化的关系。结果肾素基因rs1464816经Hardy—Weinberg遗传平衡检验不平衡;未发现肾素基因rs1464816基因型与收缩压、舒张压、血浆肾素、血管紧张素Ⅱ和醛固酮用药前后水平变化有关。结论新疆哈萨克族原发性高血压患者肾素基因rs1464816基因型与收缩压、舒张压、血浆肾素、血管紧张素Ⅱ和醛固酮用药前后变化无关。 Objective To study the relationship between REN rs1464816 different genotypes and response of blood pressure and related clinical phenotypes under antihypertensive drugs in Xinjiang Kazakans. Methods In total randomly selected 1 218 Kazakans aged 18 -69 years were investigated for hypertension and risk factors in Xinjiang. First -diagnosed hypertensive patients (n = 400) without antihypertensive medical history and complications were recruited for the current trial. All recruited subjects were randomly divided into two groups and received Captopril and Atenolol treatment respectively for three weeks. The polymorphism REN rs1464816 were genotyped in these subjects by using polymerase chain reaction -ligase detection reaction (PCR -LDR). To study the relationship between REN rs1464816 different genotypes and response of blood pressure and related clinical phenotypes ( plasma renin , Angiotensin Ⅱ aldosterone ) under antihypertensive drugs. Results The genotype frequency of REN rs1464816 was tested without genetic equilibrium in Hardy - Weinberg. No relationship was found among rs1464816 genotypes and the changes of diastolic blood pressure, plasma renin, Angiotensin Ⅱ or aldosterone after medication. Conclusions The results suggestthat the genotypes rsl464816 of renin gene might not be associated with the effect of antihypertensive treatment by Captopril and Aatenolol in Xinjiang Kazakans.
出处 《地方病通报》 2008年第3期3-7,共5页 Endemic Diseases Bulletin
基金 国家自然科学基金(30500419)
关键词 原发性高血压 肾素基因 肾素-血管紧张素-醛固酮系统 哈萨克族 Essential hypertension Renin gene Renin - angiotensin - aldosterone system Kazakans, Xinjiang
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