摘要
建立HPLC法测定尼可刹米中有关物质。采用Diamonsil C18色谱柱,以甲醇-水(30∶70)为流动相;检测波长263nm;流速1.0mL.min-1。高效液相色谱法测定尼可刹米中有关物质,降解产物与主峰达到有效分离,样品测定符合规定。该法操作简便,结果准确,专属性强,可用于尼可刹米原料中的有关物质的测定。
A HPLC method was established to determine related substance in Nikethamide. The analisis was conducted with Diamonsil C18 column at room temperature, the mobile phase was consisted of methanol-water （30 ： 70）, the detecting wavelength was 263nm, the flow was 1.0mL · min^-1. Nikethamide WAS Separated with its related substance thoroughly. The sample was analysed. The method is proved to be accurate and reliable cound be use for anslysis of the related substance in Nikethamide.
出处
《中国药事》
CAS
2008年第6期481-482,495,共3页
Chinese Pharmaceutical Affairs
