Bcr／abl融合基因阳性成人急性淋巴细胞白血病的临床研究进展
被引量：2
摘要
Bcr／abl融合基因源于Ph染色体。主要表达于慢性髓细胞白血病．亦见于20％-40％的成人急性淋巴细胞白血病（ALL），并成为ALL患者重要的独立不良预后因素。Bcr／abl^＋-ALL的临床特征和预后与常见ALL存在差异．治疗也具特殊性。本文就其研究进展作一综述。
出处
《实用医学杂志》
CAS
2008年第11期1860-1862,共3页
The Journal of Practical Medicine
参考文献22
-
1Faderl S, Kantarjian H M, Thomas D A, et al. Outcome of Philadelphia chromosome positive adult acute lympho blastic leukemia [ J ]. Leukemia and Lymphoma, 2000,36 ( 3 -4) : 263 -273.
-
2The Group Francais de Cytogenetique Hematologique. Cytogenetic abnor realities in adult acute lymphoblastic leukemia: correlations with hematologic findings and outcome [J]. Blood, 1996,87 (8) : 3135-3142.
-
3Cuneo A, Demuynck H, Ferrant A, et al. Minor myeloid component in Ph chromosome positive acute lymphoblastic leukemia:correlation with cytogenetic pattern and imp lication for poor response to therapy [J]. BrJ Haematol, 1994, 87(3) :515-522.
-
4Schrappe M, Arico M, Harbott J, et al. Philadelphia chromosome positive (Ph+) childhood acute lymphoblasticleukemia :good initial steroid response allows early prediction of a favorable treatment outcome [J]. Blood, 1998, 92(8): 2730-2741.
-
5Preti H A, O'brient S, Girah S, et al. Philadelphia chromosome positive adult acute lymphoblastic leukemia: characteristics, treatment results, and prognosis in 41 patients [J]. Am J Med, 1994,97 ( 1 ) : 60-65.
-
6Rieder H, Ludwig W D, Gassman W, et al. Prognostic significance of additional chromosome abnormalities in adult patients with Philadelphia chromosome positive acute lymphoblastic leukemia [J]. Br J Haematol, 1996,95(4) : 678 - 691.
-
7Dombret H, Gabert J, Boiron J M, et al. Outcome of treatment in adults with Philadelphia chromosome 2 positive acute lymphoblastic leukemia results of the prospective muhicenter LALA-94 trial [J]. Blood,2002, 100(7) : 2357 - 2366.
-
8Martin T G, Gajewski J L. Allogeneic stem cell transplantation for acute lymphocytic leukemia in adults. Advances in the treatment of adult acute lymphocytic leukemia [J]. Hematol/Oncol Clin North Am, 2001,15( 1 ) :97-120.
-
9Avivi I, Goldstone A H. Bone marrow transplant in Ph + ALL patients [ J ]. Bone Marrow Transplant, 2003,31 (8) : 623-632.
-
10Cornelissen J J, Carston M, Kollman C, et al. Unrelated marrow transplantation for adult patients with poor-risk acute lymphoblastie leukemia : strong graft-versus-leukemia effect and risk factors determining outcome [J]. Blood, 2001,97(6) : 1572-1577.
同被引文献13
-
1Ananymous. Morphologic,immunlogic and cytogenetic(MIC) working classification of acute lymphoblastic leukemia.Report of the workshop held in Leuven[J].Belgium,1985,(01):22-23.
-
2张之南;沈悌.血液病诊断及诊疗标准[M]北京:科学出版社,2007116-134.
-
3Rambaldi A,Attuati V,Bassan R. Molecular diagnosis and clinical relevance of t(9;22),t(4;11)and t(1;19)chromosome abnormalities in a consecutive group of 141 adute patients with acute lymphoblastic leukemia[J].Leukemia and Lymphoma,1996,(5-6):457-466.
-
4Ottmann OG,Pfeifer H. Management of Philadelphia chromosomepositive acute lymphoblastic leukemia (Ph + ALL)[J].Hematology Am Soc Hematol Educ Program,2009.371-381.
-
5Ottmann OG,Druker BJ,Sawyers CL. A phase 2 study of imatinib in patients with relapsed or refractory Philadelphia chromosome-positive acute lymphoid leukemias[J].{H}Blood,2002,(6):1965-1971.
-
6Virgili A,Brazma D,Reid AG. HSH mapping of Philadelphia negative BCR/ABL1 positive CML[J].Molecula Cytogenetics,2008,(6):1-14.
-
7Jurcek T,Razga F,Jeziskova I. Failure of molecular diagnotics in chronic myeloid leukemia:an aberran from of e13a2 BCR/ABL transcript causing false-negative results by standard poly merase chain reaction[J].{H}Leukemia & lymphoma,2010,(3):558-561.
-
8Yanada M,Takeuchi J,Sugiura I. High complete ressission rate and promising outcome by combination of imatinib and chemotherapy for newly diagnosed BCR-ABL-positive acute lymphoblastic leukemia:a phase Ⅱ study by the Japan Adult Leukemia Study Group[J].{H}Journal of Clinical Oncology,2006,(3):460-466.
-
9Thomas DA,Faderl S,Cortes J. Treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia with hyper-CVAD and imatinib mesylate[J].{H}Blood,2004,(12):4396-4407.
-
10de Labarthe A,Rousselot P,Huquet-Riqal F. Imatinib combined with induction or consolidation chemotherapy in patients with de novo Philadelphia chromosome-positive acute lymphoblastic leukemia-Results of the GRAAPH-2003 study[J].{H}Blood,2007,(4):1408-1413.
引证文献2
-
1刘蕾,白晓川,许飞,杨瑞.74例急性淋巴细胞白血病临床分析[J].宁夏医科大学学报,2013,35(5):570-572.
-
2徐芬,张长林,栾树清,闻芳,孔蕴源,万腊根.采用DCDF-FISH早期监测BCR/ABL(+)ALL患者耐药[J].中国实验血液学杂志,2014,22(1):54-57. 被引量：2
-
1陈晓丹.甲磺酸伊马替尼治疗慢性粒细胞白血病临床疗效观察[J].山西医药杂志（上半月）,2010,39(11):1076-1077.
-
2许家仁,朱广荣.老年急性淋巴细胞白血病分子生物学改变的初步观察[J].实用老年医学,2003,17(6):315-316. 被引量：1
-
3蔡静,何川.急性混合细胞白血病伴BCR/ABL融合基因阳性的临床分析[J].西部医学,2011,23(7):1276-1277. 被引量：2
-
4刘焕勋,蔡力生,杜新,孟庆祥,古庆利,陈俊雄,陈伟红,汪鹏程,汪明春.Bcr/abl融合基因阳性成人急性淋巴细胞白血病的治疗[J].临床医药实践,2006,15(6):432-433.
-
5程静,陈少谦,江晓冰,吴珊慧,刘敏.BCR/ABL融合基因阳性的急性淋巴细胞白血病的细胞形态与免疫表型特点[J].实用医学杂志,2016,32(24):4125-4128. 被引量：4
-
6游伟文,汪明春,卓家才,聂李平,李明,蔡云,蔡力生,陈俊雄,刘焕勋,汪鹏程.STI571治疗BCR/ABL融合基因阳性白血病观察[J].临床医学,2003,23(4):3-4.
-
7熊文杰,刘焕勋,黄瑞宏,张琼丽,卓家才.BCR-ABL基因阳性成人急性淋巴细胞白血病29例临床分析[J].中国热带医学,2012,12(7):868-869. 被引量：1
-
8高炳华,袁小飞,张斌,王新生.温热刺激对bcr/abl融合基因阳性的慢性粒细胞白血病细胞gp96转录水平的影响[J].军事医学,2014,38(1):78-79.
-
9李澄宇,孟凡义.CD34阳性慢性粒细胞白血病细胞生物学特征及其意义[J].国外医学（输血及血液学分册）,2005,28(5):403-405.
-
10陈晓曦,吴剑蓉,万朝敏,高举.儿童复发急性淋巴细胞白血病的临床特点及随访分析[J].华西医学,2015,30(5):885-889. 被引量：4
