城乡儿童血清中3种邻苯二甲酸酯类化合物的浓度

Serum Level of Three Kinds of PAEs in Children Living in City and Countryside in an Area in China

目的了解10～12岁城市和农村儿童血清中邻苯二甲酸酯类化合物的含量。方法于2007年1月运用反相高效液相色谱分析法(RP-HPLC)测定36名10～12岁城市儿童和38名10～12岁农村儿童血清中3种邻苯二甲酸酯类化合物[邻苯二甲酸二乙酯(DEP)、邻苯二甲酸二丁酯(DBP)和邻苯二甲酸二异辛酯(DEHP)]含量。结果城市儿童血清中DEP、DBP、DEHP含量(中位数)分别为0.0026、0.0359、0.10625mg/L,农村儿童血清中DEP、DBP、DEHP含量(中位数)分别为0.0000、0.0406、0.05245mg/L。城市儿童血清中DEP和DEHP的含量高于农村儿童,差异有统计学意义(P<0.01)。结论该地区城市儿童血清中DEP和DEHP的含量水平高于农村儿童。

Objective To understand the body burden of PAES in the children aged 10-12 years,living in city and countryside and estimate the potential hazard of PAEs for the children. Methods The reversed phase high performance liquid chromatography （RP-HPLC） was employed to determine the serum level of three kinds PAEs （DEP,DBP and DEHP） in two groups of children,including 36 city children and 38 countryside children in Jan. 2007. Results In the city children,the average serum level （median） of PAEs was 0.002 6 mg/L for DEP,0.035 9 mg/L for DBP and 0.106 25 mg/L for DEHP. In the countryside children,the serum level of PAEs was 0.000 0 mg/L for DEP,0.040 6 mg/L for DBP and 0.052 45 mg/L for DEHP. The differences of average levels of DEP and DEHP between the two groups were significant （P〈0.01）. Conclusion The serum level of DEP and DEHP in the city children is higher than that in the countryside children.