傅-克酰基化法合成直链十二烷基苯

SYNTHESIS OF n-DODECYLBENZENE BY FRIEDEL-CRAFTS ACYLATION REACTION

以月桂酸作原料，经过酰氯化，傅-克酰基化，还原等反应合成了直链十二烷基苯，并通过预处理，减压蒸馏，重结晶等方法分离并提纯，产物经^1H NMR进行了表征。优化条件为：在n（月桂酸）：n（氯化亚砜）-1：2条件下制得月桂酰氯；在n（月桂酰氯）：n（AlCl3）：n（苯）=1：1．2：8．4，80℃反应9h条件下制得十二酰基苯，再经黄呜龙还原得到最终产物直链十二烷基苯，产率可达59．200。

n-Dodecylbenzene was prepared by Minglong deoxidization, followed by purifica lauroyl chloridation, Friedel-Crafts acylation and tion with vacuum distillation and recrystallizaton Huang procedures. The optimum reaction conditions were： lauroyl chloride was first prepared with n（dodecanoic acid） ： n（thionyl chloride） of 1 ： 2; then lauroyl chloride, aluminum chloride and benzene [in the ratios of n（lauroyl chloride） ： n（aluminium chloride） ： n（benzene） = 1 ： 2 ： 8.41 reacted at 80 ℃ for 9 h; and finally Huang Minglon deoxidization of laurophenone prepared was carried out with hydrazine hydrate. After vacuum distillation and recrystallizaton, the yield of the final product was 59.2%. The final product linear dodecylbenzene was confirmed by 1H NMR characterization.