中西医结合治疗复杂性肾结石45例临床观察

Clinical Observation on Complex Renal Lithiasis with Therapy of Combination of TCM with Western Medicine,A Report of 45 Cases

目的:探讨消坚排石汤中西医结合治疗复杂性肾结石的临床疗效。方法:将75例患者随机分为治疗组45例,对照组30例。治疗组予常规西医治疗加消坚排石汤,对照组仅予常规西医疗法。结果:治疗组治愈38例,显效2例,好转3例,无效2例,总有效率为95.56%(95%CI=84.6%～99.4%);对照组治愈15例,显效3例,好转5例,无效7例,总有效率为76.67%(95%CI=57.7%～90.1%);两组综合疗效比较(u=2.6410,P=0.0092),有显著性差异;且降低BUN、Scr、尿β2-MG、血β2-MG的参数优于对照组(P(0.001)。结论:消坚排石汤中西医结合治疗复杂性肾结石疗效优于单纯西医疗法,其收益为OR=0.15(95%CI=0.03～0.80),NNT=5(95%CI=2.95～25.77)。

Objective： To investigate the curative effect of decoction of dispersing firm to remove urinary calculus combined with western medicine on complex renal lithiasis. Method： 75 cases were divided into treatment group and control group randomly. The treatment group included 45 cases, and the control group included 30 cases. Routine western medicine and decoction of dispersing firm to remove urinary calculus was given to the treatment group, and Routine western medicine was given to the control group. Result： In the treatment group, 38 cases were cured, 2 cases were excellent, 3 cases were effective, and 2 cases were ineffective. The total effective rate was 95.56% （95% CI = 84.6% - 99.4% ）. In the control group, 15 cases were cured, 3 cases were excellent, 5 cases were effective, and 7 cases were ineffective. The total effective rate was 76. 67% （95% CI = 57.7% - 99. 1% ）. The difference between the two groups was remarkable （u =2. 641 0,P =0. 009 2）. BUN, Scr, β2 - MG in urine, and β2 - MG in blood were all decreased, but the treatment group did better than the control group did （P 〈0. 001 ）. Conclusion： The curative effect of decoction of dispersing firm to remove urinary calculus combined with western medicine is better than that of only western medicine on complex renal lithiasis. OR = 0. 15 （95%CI =0. 03 -0. 80）, NNT =5 （95%CI =2.95 -25.77）.