根除幽门螺杆菌对胃窦部黏膜萎缩和肠上皮化生的影响

The Effect of Helicobacter Pylori Eradication on Atrophy of Gastric Antrum Mucosa and Intestinal Epithelium Mucosae Metaplasia

目的比较幽门螺杆菌(Hp)根除前后胃窦部黏膜的病理变化,探讨根除Hp是否可以减少黏膜萎缩和肠上皮化生程度。方法将因上腹痛进行胃镜检查的病人180例随机分为Hp根除组98例和对照组82例,对Hp根除组给予抗Hp治疗,对照组仅给予对症治疗。再次进行胃镜检查,观察两组患者胃窦部病理变化。Hp检测采用Giemsa染色法和快速尿素酶试验,萎缩和肠上皮化生诊断采用HE染色。结果对病人两次胃镜检查的胃黏膜萎缩和肠上皮化生程度进行比较,Hp根除组黏膜萎缩程度减轻(P<0.05),对照组无变化(P>0.05);Hp根除组肠上皮化生程度减轻(P<0.05),对照组加重(P<0.05)。结论根除Hp能够使胃窦黏膜萎缩程度和肠上皮化生程度减轻。

Objective To investigate the pathological changes of gastric antrum mucosa after Helicobacter pylori eradication.Methods Total 180 cases who suffered from epigastralgia and took the endoscopic examination were randomly divided into two groups,one was Hp eradication group which included 98 cases and given anti-Hp medication treatment,and the other was control group which included 82 cases and given an expectant treatment.At the end of the study,they took reexamination by gastroscope and tests on Hp by Giemsa dyeing ＆ rapid urase detection and on gastric antrum pathological changes by HE dyeing.Results In treatment group,atrophic gastritis as well as intestinal metaplasia decreased significantly after Helicobacter pylori eradication,but in control group,no change of atrophic gastritis was found while intestinal metaplasia aggravated.Conclusion The eradication of Helicobacter pylori is able to decrease atrophic gastritis and intestinal metaplasia.