摘要
目的:以生物降解材料聚β-羟基丁酸酯(PHB)为载体材料制备胰岛素微球。方法:采用液中干燥法制备,并通过均匀设计法和星点设计法来优化其制备工艺,经差示扫描量热分析(DSC)进行物相验证。结果:微球的DSC图谱中仅有PHB的峰,而胰岛素的特征峰消失。结论:证明形成了胰岛素聚β-羟基丁酸酯微球。
Objective： To prepare insulin microspheres with biodegradable poly （[3-hydroxybutyrate） as the material. Method： The microspheres were prepared by in-liquid drying method and the uniform design and central composite design were used to optimize the preparation technology. The differential scanning calorimetry was used to identify the material phase. Result： In the diagrams of differential scanning calorimetry, the characteristic peak of insulin disappeared and only that of poly（β-hydroxybutyrate） remained. Conclusion： The results showed that the insulin-poly（β-hydroxybutyrate） microspheres were formed.
出处
《中国药师》
CAS
2008年第6期613-617,共5页
China Pharmacist
基金
国家教委博士点基金项目(编号9504113)
关键词
胰岛素
聚Β-羟基丁酸酯
微球
液中干燥法
均匀设计法
星点设计法
Insulin
Poly （β-hydroxybutyrate）
Microspheres
In-liquid drying method
Uniform design
Central composite design
