抑郁症患者血浆血管紧张素Ⅱ水平的变化及其相关性研究

The plasma level of angiotensinⅡ in patients with depression before and after treatment

目的:探讨抑郁症患者血浆血管紧张素Ⅱ水平的变化及其与抑郁症的关系。方法:调查31例单相抑郁症的住院患者(抑郁症组),应用选择性5-羟色胺回收抑制剂(SSRI)药物西酞普兰治疗6周,分别于治疗前和治疗后第6周末采用放射免疫法测定患者血浆血管紧张素Ⅱ的含量;同时以汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)评定症状的严重程度,以HAMD减分率评定疗效。以30名健康志愿者为对照组。结果:抑郁症组患者治疗前血浆血管紧张素Ⅱ水平[(436.75±239.14)pg/ml]明显高于对照组[(130.42±47.85)pg/ml],差异有统计学意义(P=0.000);治疗后血浆血管紧张素Ⅱ水平[(205.97±155.00)pg/ml]较治疗前明显下降,差异有统计学意义(P=0.000);治疗前后血浆血管紧张素Ⅱ水平的变化与HAMD及HAMA总分值的减分率呈显著负相关[HAMD(r=-0.457,P=0.022);HAMA(r=-0.473,P=0.017)]。结论:抑郁症患者的血浆血管紧张素Ⅱ水平存在异常,血管紧张素Ⅱ可能参与了抑郁的病理生理过程。

Objective：To explore the change of plasma angiotensinⅡ in patients with depression,and the relationship between angiotensinⅡand depressive symptoms. Methods：Thirty-one depressed patients diagnosed with Chinese Classification and Diagnostic Criteria for Mental Disorders criteria（3rd edition） were recruited and treated with citalopram for 6 weeks,and 30 healthy volunteers recruited as controls. The plasma angiotensinⅡ was measured with radioimmunoassay before and after treatment. The severity of symptom was evaluated with the Hamilton Rating Scale for Depression（HAMD） and Hamilton Rating Scale for Anxiety（HAMA）. Results：The plasma angiotensinⅡ level was significantly higher in patients before treatment than that in controls（436.75 ± 239.14）pg/ml vs（130.42 ± 47.85）pg/ml P = 0.000,and significantly decreased after treatment（205.97 ± 155.00）pg/ml,P = 0.000. There was significantly negative correlation between the reduction of plasma angiotensinⅡand the reduction rate of HAMD and HAMA scoreHAMD（r =-0.457,P = 0.022）;HAMA（r =-0.473,P = 0.017）. Conclusion：It suggested that the angiotensinⅡmight be involved in pathophysiology of depression.