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胃肠道间质瘤26例临床分析 被引量:2

Clinical analysis of gastrointestinal tumor:A report of 26 cases
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摘要 目的探讨胃肠道间质瘤的临床特点及其诊断和治疗方法。方法回顾性分析我院2000年-2006年收治的26例胃肠道间质瘤的临床和病理资料。结果免疫组织化学检测结果:CD117的阳性率为96.1%,CD34的阳性率为80.7%。全组均行手术治疗,手术切除率100%。未发生手术并发症,无手术死亡病例。结论CD117和CD34标记阳性是诊断胃肠道间质瘤最有价值的血清学指标;肿瘤大小和核分裂象是判断胃肠道间质瘤良、恶性的重要指标;手术是其主要的治疗方法。 Objective To investigate the clinical manifestations, diagnosis and treatment of gastrointestinal stromal tumor(GIST). Methods Clinicopathological data of 26 cases of GIST from 2000 to 2006 were retrospectively analyzed. Results The positive rate of CD117 ( + )and CD34 ( + )was 96. 1 % and 80. 70% respectively. All the cases underwent operation with the resection rate being 100%. No operative complications and deaths occurred. Conclusion CD117 and CD34 are the most valuable diagnostic indexes of GIST;Tumor size and mitosis are important indexes to define malignant or benign GIST; Surgical procedures are the main treatment.
出处 《腹部外科》 2008年第3期169-170,共2页 Journal of Abdominal Surgery
关键词 胃肠道间质肿瘤 免疫组织化学 消化系统外科手术 Gastrointestial stromal tumors Immunohistochemistry Digestive system surgical procedures
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  • 1师英强,蔡宏,杜春燕.排便困难伴大便变细[J].中国实用外科杂志,2006,26(2):154-155. 被引量:5
  • 2Emory TS, Sobin LH, Lukes L, et al. Prognosis of gastrointestinal smooth-muscle (stromal) tumors: dependence on anatomic site. Am J Surg Pathol, 1999,23:82-87.
  • 3DeMatteo RP, Lewis JJ, Leung D, et al. Two hundred gastrointestinal stromal tumors: recurrence patterns and prognostic factors for survival. Ann Surg, 2000,231:51-58.
  • 4Miettinen M, Lasota J. Gastrointestinal stromal tumors-definition, clinical, histological, immunohistochemical, and molecular genetic features and differential diagnosis. Virchows Arch, 2001,438:1-12.
  • 5Fletcher CD, Berman JJ, Corless C, et al. Diagnosis of gastrointestinal stromal tumors: a consensus approach. Hum Pathol, 2002,33:459-465.
  • 6Kindblom LG, Remotti HE, Aldenborg F, et al. Gastrointestinal pacemaker cell tumor (GIPACT): gastrointestinal stromal tumors show phenotypic characteristics of the interstitial cells of Cajal. Am J Pathol, 1998,152:1259-1269.
  • 7Taniguchi M, Nishida T, Hirota S, et al. Effect of c-kit mutation on prognosis of gastrointestinal stromal tumors. Cancer Res, 1999,59:4297-4300.
  • 8Demetri GD. Identification and treatment of chemoresistant inoperable or metastatic GIST: experience with the selective tyrosine kinase inhibitor imatinib mesylate (STI571). Eur J Cancer, 2002,38 Suppl 5:S52-S59.
  • 9Ng EH, Pollock RE, Munsell MF, et al. Prognostic factors influencing survival in gastrointestinal leiomyosarcomas. Implications for surgical management and staging. Ann Surg, 1992,215:68-77.
  • 10Demetri GD, von Mehren M, Blanke CD, et al. Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N Engl J Med, 2002,347:472-480.

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  • 1Amin MB, Ma CK, Linden MD, et al. Prognostic value of Proliferating cell nuclear antigen index in gastric stromal tumors. Correlation with mitotic count and clinical outcome[J]. Am J Clin Pathol, 1993,100(4):428- 432.
  • 2Nilsson B,Bumming P, Meis-Kindblom JM. Gastrointestinal stromal tumors: the incidence, Prevalence, clinical course and Prognostication in the Preimatinib mesylate era: a PoPulation-based study in Western Sweden[J]. Cancer, 2005, 103(4): 82-829.
  • 3Trent JC, Benjamin RS.New develoPments in gastrointestinal stromal tumor. Curr OPin Oncol, 2006,18:386-395.
  • 4Amin MB, Ma CK, Linden MD, et al. Prognostic value of Proliferating cell nuclear antigen index in gastric stromal tumors. Correlation with mitotic count and clinical outcome. Am J Clin Pathol, 1993, 100(4) :428-432.
  • 5Nilsson B, Bumming P, Meis-Kindblom JM. Gastrointestinal stromal tumors : the incidence, prevalence, clinical course and prognostication in the preimatinib mesylateera:apopulation-basedstudyin westem sweden. Cancer,2005 ,103(4) :82-829.
  • 6Trent JC, Benjamin RS. New developments in gastrointestinal stromal tumor. Curr OPin Oncol,2006,18:386-395.
  • 7李良,徐其佐,王新美,李新兵,栾学荣,冯延昌.胃肠道间质瘤的临床病理及治疗分析[J].中国现代医学杂志,2008,18(5):642-643. 被引量:9
  • 8杨华伟,张传珉,茹海明,刘剑仑,杨南武.胃肠道间质瘤32例外科治疗[J].华夏医学,2008,21(3):457-459. 被引量:2
  • 9蔡炜龙,韩春蕃,吴鹤芬.胃肠道间质瘤的临床特点及预后分析[J].浙江临床医学,2008,10(11):1456-1457. 被引量:4

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