药物作用的靶点及其多效性

Target and pleiotropic effect of drug

细胞是一个复杂的有机体,包涵了众多细胞器、细胞表面的受体、各种离子通道等,在真核生物中具有极其复杂的细胞核内的物质与结构。这些复杂的细胞结构通过细胞表面与细胞核内的受体、信号转导途径等实现对刺激信号的吸收并根据不同的微环境做出相应的应答。作为一种刺激信号,药物也能够在不同的微环境及病理状态下通过不同的作用靶点产生不同的治疗效果。

Cell is a complicated organism that includes many organelles, cell surface receptors and ion channels. Especially there are a lot of complicated substance and structure in eukaryote. Furthermore, through cell surface or nucleus receptors and signal transduction pathway, cell can absorb various stimulation, at the same time, react according to the different microenvironment. As a stimulatory signal, drug can also produce different therapeutic effects through the different targets according to different microenvironment and pathologic state.