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肝脏型脂肪酸结合蛋白与代谢综合征 被引量：2

Liver fatty acid binding protein and metabolic syndrome
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摘要 肝脏型脂肪酸结合蛋白(liver fatty acid binding protein,L-FABP)基因定位于人类2号染色体短臂(2p11)上,主要表达于哺乳动物肝脏细胞,其功能是调节脂肪酸的吸收及细胞内的转运。近来研究表明L-FABP的功能状态与脂肪性肝病、肥胖、胰岛素抵抗等脂质代谢异常的疾病的发生发展关系密切。 Liver fatty acid binding protein（L-FABP） gene was identified in the short arm of human chromosome 2 （2p11 ）. It is mainly expressed in mammalian liver cells, and its function is to regulate fatty acid uptake and intracellular transport. L-FABP is closely associated with the development of fatty liver disease , obesity and insulin resistance.
作者 屈霞 欧阳冬生
机构地区 中南大学临床药理研究所
出处 《国际病理科学与临床杂志》 CAS 2008年第3期247-251,共5页 Journal of International Pathology and Clinical Medicine
基金 湖南省科技厅面上项目(2007FJ3035)~~
关键词 肝脏型脂肪酸结合蛋白 脂肪肝 肥胖 胰岛素抵抗 liver fatty acid binding protein fatty liver disease obesity insulin resistance
分类号 R589 [医药卫生—内分泌]
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参考文献25

  • 1Storch J, Thumser AE. The fatty acid transport function of fatty acid-binding proteins [J]. Biochim Biophys Acta, 2000, 1486 (1) : 28-44.
  • 2Tan NS, Shaw NS,Vinckenbosch N,et al. Selective cooperation between fatty acid binding proteins and peroxisome proliferator-activated receptors in regulating transcription [ J ]. Mol Cell Biol, 2002,22 (14) : 5114-5127.
  • 3Wolfrum C,Borrmann CM,Borchers T,et al. Fatty acids and hypolipidemic drugs regulate peroxisome proliferator-activated receptors alpha- and gamma-mediated gene expression via liver fatty acid binding protein: a signaling path to the nucleus [ J ]. Proc Natl Acad Sci USA,2001,98 (5) : 2323-2328.
  • 4Chmurzynska A. The multigene family of fatty acid-binding proteins (FABPs) : function, structure and polymorphism[ J]. J Appl Genet,2006,47 ( 1 ) : 39-48.
  • 5Wolfrum C, Buhlmann C, Roll B, et al. Variation of liver-type fatty acid binding protein content in the human hepatoma cell line HepG2 by peroxisome proliferators and antisense RNA affects the rate of fatty acid uptake [ J ]. Biochim Biophys Acta, 1999,1437 (2) : 194-201.
  • 6Martin GG, Danneberg H, Kumar LS, et al. Decreased liver fatty acid binding capacity and altered liver lipid distribution in mice lacking the liver fatty acid-binding protein gene[J]. J Biol Chem, 2003,278 (24) : 21429-21438.
  • 7Erol E,Kumar LS,Cline GW,et al. Liver fatty acid binding protein is required for high rates of hepatic fatty acid oxidation but not for the action of PPARalpha in fasting mice[ J]. FASEB J,2004,18( 2 ) : 347-349.
  • 8Glatz JF, van der Vusse GJ. Cellular fatty acid-binding proteins: their function and physiological significance [ J ]. Prog Lipid Res, 1996,35 (3) : 243-282.
  • 9Hashimoto T, Kusakabe T, Watanabe K, et al. Liver-type fatty acid- binding protein is highly expressed in intestinal metaplasia and in a subset of carcinomas of the stomach without association with the fatty acid synthase status in the carcinoma [ J]. Pathobiology, 2004,71 (3): 115-122.
  • 10Kawamura T, Kanno R, Fujii H,et al. Expression of liver-type fatty-acid-binding protein, fatty acid synthase and vascular endothelial growth factor in human lung carcinoma[J]. Pathobiology,2005, 72 (5) : 233-240.

二级参考文献8

  • 1Gertow K, Bellanda M, Eriksson P, et al. Genetic and structural evaluation of fatty acid transport protein-4 in relation to markers of the insulin resistance syndrome. J Clin Endocrinol Metab, 2004,89: 392-399.
  • 2Zeisel SH, da Costa KA, Albright CD, et al. Choline and hepatocarinogenesis in the rat. Adv Exp Med Biol, 1995, 375: 65-74.
  • 3Matsumura F. On the significance of the role of cellular stress response reactions in the toxic actions of dioxin, Biochem Pharmacol,2003, 66: 527-540.
  • 4Stahl A, Gimeno RE, Tartalia LA, et al. Fatty acid transport proteins: a current view of a growing family. Trends Endocrinol metab, 2001,12: 266-273.
  • 5Richieri GV, Low PJ, Ogata RT, et al. Thermodynamics of fatty acid binding to engineered mutants of the adipocyte and intestinal fatty acid-binding proteins. J Biol Chem, 1998, 273: 7397-7405.
  • 6Abumrad N, Coburn C, Ibrahimi A. Membrane proteins implicated in long-chain fatty acid uptake by mammalian cells: CD36, FATP and FABPm, Biochim Biophys Acta, 1999, 1441: 4-13.
  • 7Stahl A, Hirsch DJ, Gimeno RE, et al. Identification of the major intestinal fatty acid transport protein, Mol Cell, 1999, 4: 299-308.
  • 8范建高,钟岚,王国良,徐正婕,巫协宁.肥胖、高脂血症致脂肪性肝炎发病机制的探讨[J].肝脏,1999,4(3):171-171. 被引量：21

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国际病理科学与临床杂志
2008年 第3期

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