靶向肿瘤坏死因子治疗溃疡性结肠炎研究进展

Progression of TNF-targeted ulcerative colitis therapy

对于顽固性的、5-氨基水杨酸类药物治疗无效的UC患者,传统的方法是使用糖皮质激素或免疫抑制剂,常常有部分患者无法耐受其不良反应,直接导致结肠切除甚至死亡。近年来,抗肿瘤坏死因子药物治疗UC显示出良好前景,此文就靶向肿瘤坏死因子治疗UC研究的进展作一综述。

The traditional method of the patients suffered from ulcerative colitis, particularly those who was no responses to 5 aminosalicylic acid, is the use of glucocorticoids or immunosuppressants. Some patients are often unable to its tolerance side effects, and have to accept the result of colon resection or even death. In recent years, anti tumor necrosis factor drugs for treatment of ulcerative colitis have shown good prospects. A review of research progression of anti tumor necrosis factor drugs in the treatment of ulcerous colitis in this field goes as follows.