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血管活性肠肽在调节肠黏膜屏障功能中的作用 被引量：17

Effects of vasoactive intestinal peptide on the modulation of gut barrier function
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摘要 血管活性肠肽(VIP)是由28个氨基酸残基构成的脑肠肽。它既是一种胃肠激素,同时又是非肾上腺素能非胆碱能(NANC)神经递质,并参与调节肠黏膜的机械、化学、免疫屏障及肠道动力,能有效保护肠黏膜屏障功能。 Vasoactive intestinal peptide is a braingut peptide made of 28 amino- acid residues. It is not only a gut hormone, but also a nonadrenergic noncholinergic（NANC） neurotransmitter, participating in the modulation of gut mechanical,chemical, immune barriers and gut motility. It can effectively protect gut barrier function.
作者 陆忠凯 陈卫昌
机构地区 苏州大学附属第一医院
出处 《国际消化病杂志》 CAS 2008年第3期226-229,共4页 International Journal of Digestive Diseases
关键词 血管活性肠肽 肠屏障 脑肠肽 Vasoactive intestinal peptide Gut barrier Braingut peptide
分类号 R574 [医药卫生—消化系统] R285.5 [医药卫生—中药学]
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参考文献26

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  • 2Said SI, Mutt V. Polypeptide with broad biological activity: Isolation from small intestine. Science, 1970, 169: 1217-1218.
  • 3Bellinger DL, Lorton D, Romano TD, et al. Neuropeptide innervation of lymphoid organs. Ann NY Acad Sci, 1990, 594:17-33.
  • 4Martinez C, Delgado M, Abad C, et al. Regulation of VIP production and secretion by murine lymphocytes. Neuroimmunol, 1999, 93: 126-138.
  • 5Baumgart DC, Dignass AU. Intestinal barrier function. Curr Opin Clin Nutr Metab Care, 2002, 5: 685-694.
  • 6Schmitz H, Barmeyer C, Fromm M, et al. Altered tight junetion structure contributes to the impaired epithelial barrier function in ulcerative colitis. Gastroenterol, 1999, 116:301-309.
  • 7Scott KG, Meddings JB, Kirk DR, et al. Intestinal infection with Giardia spp reduces epithelial barrier function in a myosin light chain kinase-dependent fashion. Gastroenterology, 2002, 123: 1179-1190.
  • 8Yu D, Seitz PK, Selvanayagam P, et al. Effects of vasoactive intestinal peptide on adenosine 3', 5'-monophosphate, ornithine decarboxylase, and cell growth in a human colon cell line. Endocrinol, 1992, 131:1181-1193.
  • 9Banan A, Zhang Y, Losurdo J, et al. Carbonylation and disassembly of the F-actin cytoskeleton in oxidant induced barrier dysfunction and its prevention by epidermal growth factor and transforming growth alpha in a human colonic cell live. Gut, 2000, 46: 830-837.
  • 10Zandomeneghi R, Montanari P, Serra L, et al. Role of vasoae rive intestinal peptide(VIP)and somatostatin on the secretion of epidermal growth factor(EGF) : studies on duodenal tissue cultures. Regul Pept, 1990, 29: 75-80.

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国际消化病杂志
2008年 第3期

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