白细胞介素23与炎症性肠病

Relationship between interleukin-23 and inflammatory bowel disease

炎症性肠病(IBD)是一类病因不明的胃肠道慢性非特异性炎症,包括克罗恩病(CD)和溃疡性结肠炎(UC)。促炎因子和抗炎因子的失衡被视为一个重要的病因[1]。白细胞介素23(IL-23)属于前炎性因子,在IBD的发生、发展中起重要作用。此文就近年来IL-23在IBD发生、发展和治疗中的作用作一综述。

Inflammatory bowel disease（IBD）is described as chronic non-specific gastrointestinal disease of unknown etiology. It contains ulcerative colitis （UC） and Crohn＇s disease （CD）. Disequilibrium between inflammatory cytokine factor and anti inflammatory factor play an important role in genesis of IBD. IL-23 which belongs to pro-inflammatory factors which takes part in the genesis of IBD. The purpose of the paper is to describe the function of IL-23 in the genesis, development and treatment of IBD.