胆囊结石病人胆囊胆汁中游离Ca^(2+)升高

The Elevation of Free Ca^(2+)in Gallbladder Bilefrom Patients with Gallstone

胆囊结石成因中钙非常重要，本研究旨在了解胆囊结石病人与非结石病人间睑汁中是否钙有量的不同。术中穿刺胆囊从57例病人抽取胆汁，其中22例病人无胆囊结石，19例为胆固醇结石，16例为胆色素结石，测定胆汁游离Ca2+，胆色素结石病人为1．79±0．44mmol／L，胆固醇结石病人为1．31±0．32mmol／L，非结石病人为1．05±0．10mmol／L。明石病人与非结石病人间测定值有明显的重叠，胆色素组与胆固醇组间P＜0．05，胆色素结石组与非结石组间P＞0．05，其他组间P＞0．05。这种异常变化与胆囊结石形成有关。

Biliary calcium is believed to be of great important in gallstone pathogenesis.This study was per formed to determine if quantitative difference in calcium is present in gallbladder bile from patients with and without gallstones. Bile was obtained by direct gallbladder aspiration from 57 patients undergoing epiabdominal surgery. Twenty-two had no evidence of gallstones, 19 had cholesterol gallstones, and 16 had black pigment stones, Free Ca2+ ion ranged from 1. 5 ± 0. 1 0, 1 - 31 ±0. 32, 1. 79 ± 0. 44mmol/L, respectively, Considerable overlap was observed between patients with and without gallstones,Free Ca2+was greater in gallbladder lile form gallstone patients,the black pigment gallstone patients were the biggest (P<0. 05) . The elevation of free Ca2+may play a role in gallstone pathogenesis-