凋亡抑制蛋白Survivin在儿童急性白血病中的表达及临床意义

Expression and clinical significance of inhibitor of apoptosis protein Survivin in children with acute leukemia

目的探讨凋亡抑制蛋白Survivin在儿童急性白血病(AL)中的表达及其临床意义。方法49例AL患儿,其中初诊未治26例,治疗后完全缓解23例;对照组为10例非恶性血液病患儿。应用免疫组织化学方法检测骨髓细胞Survivin蛋白的表达。结果AL初诊未治患儿Survivin蛋白表达阳性率(65.38%)显著高于治疗后完全缓解患儿(17.39%)和对照组(10.00%,P<0.017);初诊未治患儿Survivin蛋白表达阳性率在急性淋巴细胞白血病(63.16%)和急性髓细胞白血病(71.43%)比较无显著性差异(P>0.05)。结论Survivin可能通过抑制肿瘤细胞的凋亡参与了儿童AL的发生发展,为儿童AL的治疗提供了新的思路。

Objective To investigate the expression and clinical significance of inhibitor of apoptosis protein Survivin in children with acute leukemia（AL）. Methods . Among 49 patients with AL,26 cases were diagnosed first time and weren＇t treated,23 cases were complete remission after treatment. The expression of Survivin protein was detected by immunohistochemical assay in 49 children with AL and 10 children without malignant blood disease. Results Survivin protein positive expression rate in 26 newly diagnosed children with AL （65.38%） is significantly higher than that in complete remission children（ 17.39% ） and the children in control group （ 10.00% , P 〈 0.017 ）. There is no significant difference in the positive expression of Survivin between the newly diagnosed acute lymphoblastic leukemia （63.16%）and acute myeloblastic leukemiapatients （71. 43% ,P 〉 0.05）, Conclusion Survivin may participate in the pathogenesis and progress of AL by inhibiting the apoptosis of tumor cell. It provides a new strategy for the therapy of AL in Children.