前列腺炎患者葡萄球菌的分离、药物敏感性试验及临床意义

Isolation,drug susceptibility and clinical significance of Staphylococcus on prostatitis patients

目的探讨细菌性前列腺炎患者葡萄球菌的感染状况及抗菌药物敏感性。方法回顾分析421例前列腺炎患者标本的细菌学和药物敏感性试验结果。结果421例前列腺液标本,273例分离出细菌,共分离出15个种别共计278株病原菌,其中金黄色葡萄球菌占57.2%,凝固酶阴性葡萄球菌占17.3%;葡萄球菌对青霉素G、红霉素、白霉素耐药率为88%～97%,对氟喹诺酮类耐药率为33%～50%,对丁胺卡那霉素、头孢唑啉、新霉素、利福平和头孢哌酮耐药率均<30%,对万古霉素全部显示敏感。结论葡萄球菌是细菌性前列腺炎的最常见病原菌,对临床常用抗菌药物具有较高的耐药性,葡萄球菌对万古霉素、丁胺卡那霉素、头孢唑啉、新霉素、利福平和头孢哌酮较为敏感。

Objective To study the infection and sensitivity to antimierobial agents of staphylococcus of bacterial prostatitis patients. Methods The results of bacteriology and drug suseeptlbility of 421 patients,who were suffered from prostatitis, were analysed retrospectively. Results In the 421 succus prostaticus samples, 278 strains pathogenic microorganisms of 15 genera were isolated from the 273 succus prostaticus samples, and the major pathogenic microorganisms was Staphylococcus aureus （57.2%） and Coagulase negative staphylocous（ 17.3% ）. The drug resistance rate of staphylococcus to penicillinG, erythromytin and albomycin was 88% -97%, and it was 33% -50% to fluoroquinolones. The drug resistance rate of staphylococcus to amikacin ,cefazolin ,nemycin ,rifampicin and cefoperazone was lower than 30% ,and they all appeared susceptible to vancomycin. Conclusion Staphylococcus is the main germ of bacterial prostatitis and it appears high drug resistance to usual antibacterials. Staphylococcus is susceptible to vancomycin, amikacin, cefazolin, neomycin, rifampicin and cefoperazone.