胫前黏液水肿的治疗

Treatment of pretibial myxedema

胫前黏液水肿为自身免疫性甲状腺疾病的特殊表现，多见于Graves病，是主要发生于胫骨前及足背部的浸润性皮肤病变，一般无症状，少数有瘙痒或微痛、色素沉着，其发病机制尚不完全清楚。大部分轻症患者无需治疗，症状明显的中重度患者的治疗较困难且易复发，对中度患者或有美容要求者需要局部治疗如局部外敷皮质激素，更严重者需要系统性免疫调节治疗等。本文就胫前黏液水肿的局部治疗、系统治疗及辅助治疗等治疗方法及疗效作一综述。

Pretibial myxedema,as often seen in Graves＇ disease,is a special manifestation of autoimmune thyroid disorder. This invasional dermatonosis mainly develops in anterior tibia and dorsum pedis without symptom,and someone could have a sensation of itch or light painful hyperpigmentation. The pathogenesis is not completely clear yet. Most mild cases need no treatment, while frankly moderate and severe cases are difficult to cure and frequently recur after therapy. In severe cases and when there is cosmetic concern,topical corticosteroids applied under occlusive dressing are beneficial. In more severe cases, systemic immunomodulation may be necessary. This review provides partial and general treatments of pretibial myxedema as well as their effects.