恶性嗜铬细胞瘤的非手术治疗进展

Non-operative treatment for malignant pheochromocytoma

恶性嗜铬细胞瘤的治疗包括外科手术、^131l-间碘苄胍（MIBG）放射治疗、化学治疗和动脉栓塞治疗等。从疗效看，^131l-MIBG放射治疗和环磷酰胺、长春新碱以及氮烯咪胺联合化学治疗是比较有效的治疗方法，且不良反应相对较小。热休克蛋门（HSP）90抑制剂是一具有诱人前景的新型抗肿瘤药。本文对恶性嗜铬细胞瘤的非手术治疗方法进行简要综述。

Treatments for malignant pheochromocytoma include surgical debulking, ^131l-MIBG radiotherapy, chemotherapy and transcatheter arterial embolization. MIBG radiotherapy and combined chemothera- py of cyclophusphamide,vincristine, dacarbazine are comparable with respect to response rate and toxicity. Inhibition of HSP90 is an important element of multi-modal concepts for therapy of malignant pheochromocytoma. This review focuses on the recent advances in the non-operative treatment for malignant pheochromocytoma.