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TEL-AML1阳性儿童急性淋巴细胞白血病IgH及TCRγ基因重排的研究 被引量：3

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摘要 t（12；21）是儿童急性淋巴细胞白血病（ALL）中最常见的染色体易位，占B-ALL的16％-36％^[1]；该易位导致12p13上的TEL基因与21q22上的AML1基因融合，形成TEL-AML1融合基因。已有研究证实单独TEL-AML1融合基因并不能导致白血病发生，提示还存在其他协同因素^[2]。
作者 曹增 李承文 艾晓非 王晓静 王芳 孙海燕 徐世才 刘旭平 肖志坚
机构地区 中国医学科学院北京协和医学院血液学研究所血液病医院实验血液学国家重点实验室
出处 《中华血液学杂志》 CAS CSCD 北大核心 2008年第6期408-409,共2页 Chinese Journal of Hematology
基金 基金资助：新世纪优秀人才支持计划（NCET-05-0173）
关键词 儿童急性淋巴细胞白血病 TEL-AML1 TCRΓ基因重排 IGH 染色体易位 阳性 融合基因 B-ALL
分类号 R686 [医药卫生—骨科学]
  • 相关文献

参考文献8

  • 1Romana SP, Poirel H, Leconiat M, et al. High frequency of t( 12; 21 ) in childhood B-lineage acute lymphoblastic leukemia. Blood, 1995, 86: 4263-4269.
  • 2Rothman R, Trakhtenbrot L, Bielorai B, et al. Co-existence of multiple subclones in TEL-AML1 at diagnosis of acute lymphoblas- tic leukaemia in association with submicroscopic deletion of AML1. Br J Haematol, 2005, 129:491-498.
  • 3van Dongen JJ, Langerak AW, Broggemann M, et al. Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receplor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936. Leukemia ,2003,17:2257-2317.
  • 4林冬,刘世和,竺晓凡,薄丽津,李承文,陈玉梅,刘旭平,秦爽,代芸,王建祥.t(12;21)儿童急性淋巴细胞白血病的研究[J].中华血液学杂志,2004,25(1):17-21. 被引量：9
  • 5Loh ML, Goldwasser MA, Silverman LB,et al. Prospective analysis of TEL/AML1-positive patients trealed on Danna-Farber Cancer Institute Consortium Protocol 95-01. Blood, 2006, 107: 4508- 4513.
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二级参考文献10

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  • 3Romana SP,Poirel H,le Coniat M,et al.High frequency of t(12;21)in childhood B-Lineage acute lymphoblastic leukemia[].Blood.1995
  • 4Golub TR,Barker GF,Bohlander SK,et al.Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia[].Proceedings of the National Academy of Sciences of the United States of America.1995
  • 5Pui CH.Childhood leukemia[].The New England Journal of Medicine.1995
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  • 7Shurtleff SA,Buijs A,Behm FG,et al.TEL AML1 fusion resulting from a cryptic t(12;21) is the most common genetic lesion in pediatric ALL and defines a subgroup of patients with an excellent prognosis[].Leukemia.1995
  • 8van Dongen JJM,Macintyre EA,Gabert JA,et al.Standardized RT-PCR analysis of fusion gene transcripts from chromosome aberrations in acute leukemia for detection of minimal residual disease[].Leukemia.1999
  • 9Borkhardt A,Cazzaniga G,Viehmann S,et al.Incidence and clinical relevance of TEL AML1 fusion genes in children with acute lymphoblastic leukemia enrolled in the German and Italian multicenter therapy trials[].Blood.1997
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共引文献8

同被引文献24

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  • 6Langerak AW,Groenen PJ,Brüggemann M,et al.EuroClonality/BIOMED-2 guidelines for interpretation and reporting of Ig/TCR clonality testing in suspected lymphoproliferations[J].Leukemia,2012,26(10):2159-2171.
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  • 8van Dongen JJ, Langerak AW, Brtiggemann M, et al. Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4- CT98- 3936 [J]. Leukemia, 2003, 17 (12): 2257-2317.
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引证文献3

二级引证文献9

中华血液学杂志
2008年 第6期

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