PET／CT对头颈部肿瘤放射治疗计划的作用

PET/CT fusionin radiotherapy treatment planning of head and neck cancer

目的探讨PET／CT对头颈部肿瘤放射治疗计划的作用。方法16例头颈部肿瘤患者行PET／CT和定位CT检查，根据检查结果对16例患者进行TNM分期，比较其分期结果。将定位CT图像传入三维治疗计划系统（TPS），在定位CT图像上勾画大体肿瘤体积（GTV），即CT-GTV；参考PET／CT融合图像在定位CT图像上勾画PET／CT-GTV，比较PET／CT-GTV和CT-GTV。采用Stata7．0软件分析数据，t检验用于比较PET／CT-GTV和CT-GTV。结果PET／CT使7例患者TNM分期发生改变。PET／CT-GTV和CT—GTV中位值分别为84．3（46～364）cm^3和116．2（58—472）cm^3，差异有统计学意义（t=-4．3186，P=0．0005）。结论PET／CT能提高头颈部肿瘤分期和肿瘤靶区定位的准确性。

Objective The aim of this study was to investigate the value of PET/CT in radiation treatment planning of head and neck cancer. Methods Sixteen patients with head and neck cancer underwent PET/CT and enhanced CT imaging. TNM stage was analyzed based on PET/CT and CT. Gross tumor volume （GTV） of PET/CT （PET/CT-GTV） and CT （CT-GTV） were analyzed. Stata 7.0 was used for data analysis, PET/CT-GTV and CT-GTV were compared with t test. Results Based on PET/CT, changes in TNM stage occurred in 7 patients. The median PET/CT-GTV and CT-GTV were 84.3 （46 -364） cm^3 and 116.2 （58 -472） cm^3, respectively, which had a statistically significant difference（t = -4. 318 6, P = 0. 000 5 ）. Conclusion PET/CT can increase the accuracy of staging and defining the field and target vol- umes for radiation therapy of head and neck cancer.