摘要
目的:研究皮肤鳞状细胞癌(CSCC)和正常皮肤组织中生存素基因的表达与CD3+T细胞浸润情况,探讨它们在CSCC发生、发展中的可能作用。方法:采用免疫组织化学SP法检测60例CSCC组织和10例正常皮肤组织中生存素蛋白的表达及CD3+T细胞的浸润情况。结果:生存素蛋白在CSCC中阳性表达率为68.33%(41/60),正常皮肤组织中生存素无表达。生存素蛋白的阳性表达率及CD3+T细胞的数量均与CSCC的病理分级、淋巴结转移有关,但二者之间无显著相关性。结论:生存素蛋白可作为判断CSCC恶性程度、评价预后的指标。CD3+T细胞可成为反映机体抗肿瘤特异性细胞免疫状态和生物学行为及判断患者预后的重要指标。
Objective： To investigate the expression of survivin and CD3^＋ T lymphocytes infiltration in cutaneous squamous cell carcinoma （CSCC） and to explore their possible role in the pathogenesis of CSCC. nethods： The expression of survivin and CD3^＋ T lymphocytes were measured with SP method in 60 CSCC and 10 normal controls. Results： The positivity rate of survivin in CSCC was 68.33% （41/60） and there was no observed expression of survivin in normal controls. The positivity rate of both survivin and the number of CD3^＋ T lymphocytes were correlated with the tumor pathological grade and lymph node metastases. There was no correlation in the expression of survivin and the infiltration of CD3^＋ T lymphocytes. Conclusion： survivin can be used for evaluating the malignant degree of CSCC and predicting the prognosis of the patients with CSCC. The expression of CD3^＋ T lymphocytes may be useftd in estimating the local immune status and biological behaviors and predicting the prognosis of CSCC patients.
出处
《中国麻风皮肤病杂志》
2008年第6期420-423,共4页
China Journal of Leprosy and Skin Diseases
